Publication Name	World Journal of Clinical Cases
Manuscript ID	59757
Country	China

Received	2020-11-03 14:38
Peer-Review Started	2020-11-03 14:39
To Make the First Decision
Return for Revision	2021-02-12 02:22
Revised	2021-02-22 23:23
Second Decision	2021-03-10 06:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-03-11 03:14
Articles in Press	2021-03-11 03:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-03-16 02:53
Typeset the Manuscript	2021-03-25 01:08
Publish the Manuscript Online	2021-04-22 12:14

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Case Report
Article Title	Crumbs homolog 2 mutation in two siblings with steroid-resistant nephrotic syndrome: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Lu, Yan-Nan Guo and Li-Qun Dong
ORCID	Author(s) ORCID Number Jing Lu http://orcid.org/0000-0001-6606-8460 Yan-Nan Guo http://orcid.org/0000-0002-0024-2806 Li-Qun Dong http://orcid.org/0000-0002-1542-7555
Funding Agency and Grant Number
Corresponding Author	Li-Qun Dong, MD, PhD, Professor, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20 Section 3 South Renmin Road, Chengdu 610041, Sichuan Province, China. dongliqun@scu.edu.cn
Key Words	Steroid-resistant nephrotic syndrome; Crumbs homolog 2; Proteinuria; Compound heterozygous mutation; Glomerulosclerosis; Renal biopsy; Case report
Core Tip	Crumbs homolog 2 (CRB2) mutation is related to early-onset steroid-resistant nephrotic syndrome (SRNS). We here report two siblings with a novel compound heterozygous CRB2 mutation. We also reviewed the literature and found that CRB2 mutations related to SRNS often occur in exons 7, 10 and 12. Clinical manifestations of SRNS caused by CRB2 mutations, such as edema, are often less severe than in other forms of SRNS.
Publish Date	2021-04-22 12:14
Citation	Lu J, Guo YN, Dong LQ. Crumbs homolog 2 mutation in two siblings with steroid-resistant nephrotic syndrome: Two case reports. World J Clin Cases 2021; 9(13): 3056-3062
URL	https://www.wjgnet.com/2307-8960/full/v9/i13/3056.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i13.3056

Full Article (PDF)	WJCC-9-3056.pdf
Full Article (Word)	WJCC-9-3056.docx
CARE Checklist–2016	59757-CARE-Checklist–2016-revision.pdf
Manuscript File	FP8750_ce17_CE1MS-CL.docx
Answering Reviewers	59757-Answering reviewers.pdf
Audio Core Tip	59757-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	59757-Conflict-of-interest statement.pdf
Copyright License Agreement	59757-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	59757-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	59757-Language certificate.pdf
Peer-review Report	59757-Peer-review(s).pdf
Scientific Misconduct Check	59757-Bing-Yan JP-1.jpg
Scientific Misconduct Check	59757-Bing-Fan JR-2.png
Scientific Misconduct Check	59757-Scientific misconduct check.pdf
Scientific Editor Work List	59757-Scientific editor work list.pdf
CrossCheck Report	59757-CrossCheck report.pdf
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