Publication Name	World Journal of Gastroenterology
Manuscript ID	5983
Country	China

Received	2013-09-29 14:41
Peer-Review Started	2013-09-30 16:03
To Make the First Decision	2013-11-12 18:31
Return for Revision	2013-11-14 16:14
Revised	2013-12-03 22:31
Second Decision	2014-01-05 14:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-05 15:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-17 17:41
Typeset the Manuscript	2014-03-25 20:41
Publish the Manuscript Online	2014-04-04 15:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	How hepatitis C virus invades hepatocytes: The mystery of viral entry
Manuscript Source	Invited Manuscript
All Author List	Yong-Zhe Zhu, Xi-Jing Qian, Ping Zhao and Zhong-Tian Qi
Funding Agency and Grant Number	Funding Agency Grant Number National S and T Major Project for Infectious Diseases Control 2012ZX10002003-004-010 National Natural Science Foundation of China 81171564 National Natural Science Foundation of China 81273557 National Natural Science Foundation of China 81302812 Medical Youth Science Program 13QNP100 Shanghai Municipal Natural Science Foundation 13ZR1449300 Shanghai LAD Project B901
Corresponding Author	Zhong-Tian Qi, PhD, Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China. qizt@smmu.edu.cn
Key Words	Hepatitis C virus; Virus entry; Hepatocytes; Receptor; Host kinase; Antiviral target
Core Tip	Cell entry is the first step in viral infection and replication, which offers an important target for antiviral therapy. Hepatitis C virus (HCV) cell entry is a complex multi-step process, involving a several cellular factors that trigger virus uptake into the hepatocytes. This review summarizes the current understanding about how cell surface molecules are involved in HCV attachment, internalization, and membrane fusion, and how host cell kinases regulate virus entry. The advances of the potential antiviral agents targeting this process are introduced.
Publish Date	2014-04-04 15:11
Citation	Zhu YZ, Qian XJ, Zhao P, Qi ZT. How hepatitis C virus invades hepatocytes: The mystery of viral entry. World J Gastroenterol 2014; 20(13): 3457-3467
URL	http://www.wjgnet.com/1007-9327/full/v20/i13/3457.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i13.3457

Full Article (PDF)	WJG-20-3457.pdf
Full Article (Word)	WJG-20-3457.doc
Manuscript File	5983-Review.doc
Answering Reviewers	5983-Answering reviewers.pdf
Copyright License Agreement	5983-Copyright assignment.pdf
Peer-review Report	5983-Peer review(s).pdf
Scientific Editor Work List	5983-Scientific editor work list.doc