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Publication Name World Journal of Gastroenterology
Manuscript ID 5983
Country of Manuscript Source China
2013-09-29 14:41
Peer-Review Started
2013-09-30 16:03
To Make the First Decision
2013-11-12 18:31
Return for Revision
2013-11-14 16:14
2013-12-03 22:31
Second Decision
2014-01-05 14:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-05 15:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-03-17 17:41
Typeset the Manuscript
2014-03-25 20:41
Publish the Manuscript Online
2014-04-04 15:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Topic Highlights
Article Title How hepatitis C virus invades hepatocytes: The mystery of viral entry
Manuscript Source Invited Manuscript
All Author List Yong-Zhe Zhu, Xi-Jing Qian, Ping Zhao and Zhong-Tian Qi
Funding Agency and Grant Number
Funding Agency Grant Number
National S and T Major Project for Infectious Diseases Control 2012ZX10002003-004-010
National Natural Science Foundation of China 81171564
National Natural Science Foundation of China 81273557
National Natural Science Foundation of China 81302812
Medical Youth Science Program 13QNP100
Shanghai Municipal Natural Science Foundation 13ZR1449300
Shanghai LAD Project B901
Corresponding author Zhong-Tian Qi, PhD, Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China. qizt@smmu.edu.cn
Keywords Hepatitis C virus; Virus entry; Hepatocytes; Receptor; Host kinase; Antiviral target
Core Tip Cell entry is the first step in viral infection and replication, which offers an important target for antiviral therapy. Hepatitis C virus (HCV) cell entry is a complex multi-step process, involving a several cellular factors that trigger virus uptake into the hepatocytes. This review summarizes the current understanding about how cell surface molecules are involved in HCV attachment, internalization, and membrane fusion, and how host cell kinases regulate virus entry. The advances of the potential antiviral agents targeting this process are introduced.
Publish Date 2014-04-04 15:11
Citation Zhu YZ, Qian XJ, Zhao P, Qi ZT. How hepatitis C virus invades hepatocytes: The mystery of viral entry. World J Gastroenterol 2014; 20(13): 3457-3467
Url http://www.wjgnet.com/1007-9327/full/v20/i13/3457.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i13.3457
Full Article (PDF) WJG-20-3457.pdf
Full Article (Word) WJG-20-3457.doc
Manuscript File 5983-Review.doc
Answering Reviewers 5983-Answering reviewers.pdf
Copyright License Agreement 5983-Copyright assignment.pdf
Peer-review Report 5983-Peer review(s).pdf
Scientific Editor Work List 5983-Scientific editor work list.doc