Publication Name	World Journal of Gastroenterology
Manuscript ID	5986
Country	Poland

Received	2013-10-03 17:27
Peer-Review Started	2013-10-04 16:02
To Make the First Decision	2013-12-26 10:49
Return for Revision	2013-12-27 15:49
Revised	2014-01-17 19:44
Second Decision	2014-04-23 09:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 10:05
Articles in Press	2014-05-23 11:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-08 23:10
Typeset the Manuscript	2014-07-20 14:13
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years
Manuscript Source	Invited Manuscript
All Author List	Mariusz Panczyk
Funding Agency and Grant Number
Corresponding Author	Mariusz Panczyk, PharmD, PhD, Division of Teaching and Outcomes of Education, Faculty of Health Science, Medical University of Warsaw, Zwirki i Wigury 61, 02-091 Warsaw, Poland. mariusz.panczyk@wum.edu.plTelephone: +48-22-5720490
Key Words	Pharmacogenetics; Pharmacogenomics; Drug resistance; Colorectal cancer; Chemoresistance; Individualized medicine
Core Tip	Insufficient effectiveness of chemotherapy is still the most important factor limiting the successful treatment of patients with colorectal cancer (CRC). Drug resistance in anticancer therapy has been recognized virtually from the very beginning, as cytostatic drugs were first used in oncology practice. Intensive research on the causes of low sensitivity in colorectal cancer cells to such drugs as fluoropyrimidines, irinotecan and oxaliplatin, has resulted in evidence on the importance of genetic factors in phenotype conditioning of drug resistance. This review is a synthetic presentation of drug resistance in the context of its role in chemotherapy, and the potential clinical use of different biomarkers in individualization of CRC patient treatment.
Publish Date	2014-08-07 10:34
Citation	Panczyk M. Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years. World J Gastroenterol 2014; 20(29): 9775-9827
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/9775.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.9775

Full Article (PDF)	WJG-20-9775.pdf
Full Article (Word)	WJG-20-9775.doc
Manuscript File	5986-Review.docx
Answering Reviewers	5986-Answering reviewers.pdf
Copyright License Agreement	5986-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5986-Language certificate.pdf
Peer-review Report	5986-Peer reviews.pdf
Scientific Editor Work List	5986-Scientific editor work list.doc