Publication Name	World Journal of Gastroenterology
Manuscript ID	5987
Country	United States

Received	2013-09-29 14:54
Peer-Review Started	2013-09-30 16:25
To Make the First Decision	2013-12-16 17:47
Return for Revision	2013-12-18 09:35
Revised
Second Decision	2014-01-20 16:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 18:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-10 20:21
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Immunosuppressive therapies for inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Talia Zenlea and Mark A Peppercorn
Funding Agency and Grant Number
Corresponding Author	Talia Zenlea, MD, Director of Inflammatory Bowel Diseases, Center for Women’s Gastrointestinal Medicine, The Women’s Medicine Collaborative, Alpert Medical School, Brown University, 146 West River St, Providence, RI 02904, United States. taliazenlea@gmail.com
Key Words	Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Immunosuppressives; Tumor necrosis factor inhibitors
Core Tip	This manuscript reviews the current status of immunosuppressive therapy for inflammatory bowel disease. It describes the mechanism of action, clinical efficacy and adverse effects of immunomodulators including azathioprine, 6-mercaptopurine, methotrexate, and cyclosporine and biologics including anti-tumor necrosis factor (TNF) agents and adhesion molecule inhibitors. It emphasizes the role of azathioprine, 6-mercaptopurine, and methotrexate in the long-term maintenance of Crohn’s disease, the utility of cyclosporine in severe refractory ulcerative colitis and the unique role of anti-TNF agents in the remission induction and maintenance of difficult to treat patients with Crohn’s disease and ulcerative colitis.
Publish Date	2014-03-27 12:04
Citation	Zenlea T, Peppercorn MA. Immunosuppressive therapies for inflammatory bowel disease. World J Gastroenterol 2014; 20(12): 3146-3152
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3146.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3146

Full Article (PDF)	WJG-20-3146.pdf
Full Article (Word)	WJG-20-3146.doc
Manuscript File	5987-Review.docx
Answering Reviewers	5987-Answering reviewers.pdf
Copyright License Agreement	5987-Copyright assignment.pdf
Peer-review Report	5987-Peer review(s).pdf
Scientific Editor Work List	5987-Scientific editor work list.doc