Publication Name	World Journal of Gastroenterology
Manuscript ID	5988
Country	China

Received	2013-09-29 14:58
Peer-Review Started	2013-09-30 16:32
To Make the First Decision	2013-10-14 20:57
Return for Revision	2013-10-15 11:27
Revised
Second Decision	2013-11-18 21:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-19 12:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-26 21:50
Typeset the Manuscript	2013-12-18 09:14
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Topic Highlights
Article Title	Antiviral treatment of hepatitis C virus infection and factors affecting efficacy
Manuscript Source	Invited Manuscript
All Author List	Yan Zhu and Song Chen
Funding Agency and Grant Number
Corresponding Author	Dr. Song Chen, Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Shapingba District, Chongqing 400038, China. cs196@medmail.com.cn
Key Words	Hepatitis C virus; Treatment; Interferon; Protease inhibitors; IL28B protein; Polymorphisms; Viral load; Genotype; Hepatic steatosis
Core Tip	Understanding the effectiveness and affecting factors of antiviral regimens are critical for making informed treatment decisions for hepatitis C virus (HCV) infection. In this review, we have summarized the history of anti-HCV agents from interferon to the direct-acting antiviral drugs (DAAs) without polyethylene glycol interferon-? therapies and the affecting factors of antiviral treatment, focusing on investigating the optimal combination of antiviral therapies to achieve higher efficacy and better medication compliance. Although the efficacy of DAAs is significantly improved, many unmet needs and questions remain, such as avoidance of cross-resistance, the remaining high incidence of side effects, the role of IL28B status as well as the management of patients who do not respond to therapy.
Publish Date	2014-01-20 16:41
Citation	Zhu Y, Chen S. Antiviral treatment of hepatitis C virus infection and factors affecting efficacy. World J Gastroenterol 2013; 19(47): 8963-8973
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/8963.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.8963

Full Article (PDF)	WJG-19-8963.pdf
Manuscript File	5988-Review.doc
Answering Reviewers	5988-Answering reviewers.pdf
Copyright License Agreement	5988-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5988-Language certificate.pdf
Peer-review Report	5988-Peer review(s).pdf
Scientific Editor Work List	5988-Scientific editor work list.doc