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Articles Published Processes
1/26/2021 6:58:53 AM | Browse: 538 | Download: 1347
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Received |
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2020-10-13 08:04 |
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Peer-Review Started |
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2020-10-13 08:04 |
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To Make the First Decision |
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Return for Revision |
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2020-12-04 02:36 |
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Revised |
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2020-12-09 04:53 |
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Second Decision |
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2020-12-24 08:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-12-25 05:18 |
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Articles in Press |
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2020-12-25 05:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-01-12 21:14 |
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Typeset the Manuscript |
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2021-01-20 12:18 |
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Publish the Manuscript Online |
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2021-01-26 06:58 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Basic Study |
| Article Title |
Selective ablation of type 3 adenylyl cyclase in somatostatin positive interneurons produces anxiety- and depression-like behaviors in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Yu Yang, Zhao-Liang Ma, Daniel R Storm, Hong Cao and Yu-Qiu Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81771208 |
| National Natural Science Foundation of China |
81971043 |
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| Corresponding Author |
Hong Cao, MD, PhD, Associate Professor, Department of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institutes of Integrative Medicine, Fudan University, Rm 1202 Mingdao Building, No. 131 Dong'an Road, Shanghai 200032, China. hongcao@fudan.edu.cn |
| Key Words |
Type 3 adenylyl cyclase; Somatostatin; Parvalbumin; Anxiety; Depression; Mice |
| Core Tip |
Dysfunction of cortical GABAergic interneurons are thought to contribute to the pathophysiology of stress-related psychiatric disorders. Little is known about the regulation of GABAergic interneurons in depression. Type 3 adenylyl cyclase (AC3) is important for the neuronal excitability and was reported as a top-ranked gene in major depressive disorder (MDD). Here, we found that majority of somatostatin-positive (SST+) and parvalbumin-positive (PV+) GABAergic interneurons express AC3. Selective disruption of AC3 in SST+ but not PV+ interneurons caused anxiety and depression-like behaviors. Our data suggest that AC3 in specific subtype interneurons played a key role in the etiology of depression, providing new insights for therapeutic interventions for the treatment of MDD. |
| Publish Date |
2021-01-26 06:58 |
| Citation |
Yang XY, Ma ZL, Storm DR, Cao H, Zhang YQ. Selective ablation of type 3 adenylyl cyclase in somatostatin positive interneurons produces anxiety- and depression-like behaviors in mice. World J Psychiatr 2021; 11(2): 35-49 |
| URL |
https://www.wjgnet.com/2220-3206/full/v11/i2/35.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v11.i2.35 |
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