Publication Name	World Journal of Gastroenterology
Manuscript ID	6003
Country	Italy

Received	2013-09-29 17:43
Peer-Review Started	2013-09-30 12:38
To Make the First Decision	2013-12-26 11:08
Return for Revision	2013-12-26 14:58
Revised
Second Decision	2014-02-27 10:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-27 12:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-27 20:50
Typeset the Manuscript	2014-05-13 16:28
Publish the Manuscript Online	2014-06-16 16:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis
Manuscript Source	Invited Manuscript
All Author List	Marco Scarpa, Ignazio Castagliuolo, Carlo Castoro, Anna Pozza, Melania Scarpa, Andromachi Kotsafti and Imerio Angriman
Funding Agency and Grant Number
Corresponding Author	Marco Scarpa, MD, PhD, Surgical Oncology Unit, Veneto Institute of Oncology (IOV-IRCCS), via Gattamelata 64, 35128 Padova, Italy. marcoscarpa73@yahoo.it
Key Words	Colorectal cancer; Ulcerative colitis; Carcinogenesis; Immune surveillance
Core Tip	The ulcerative colitis (UC)-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer. In fact, in UC, early events are represented by oxidative DNA damage and DNA methylation that can produce inhibition of oncosuppressor genes, mutation of p53, aneuploidy, and microsatellite instability. Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis.
Publish Date	2014-06-16 16:19
Citation	Scarpa M, Castagliuolo I, Castoro C, Pozza A, Scarpa M, Kotsafti A, Angriman I. Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis. World J Gastroenterol 2014; 20(22): 6774-6785
URL	http://www.wjgnet.com/1007-9327/full/v20/i22/6774.htm
DOI	10.3748/wjg.v20.i22.6774

Full Article (PDF)	WJG-20-6774.pdf
Full Article (Word)	WJG-20-6774.doc
Manuscript File	6003-Review.doc
Answering Reviewers	6003-Answering reviewers.pdf
Copyright License Agreement	6003-Copyright assignment.pdf
Peer-review Report	6033-Peer review(s).pdf
Scientific Editor Work List	6003-Scientific editor work list.doc