Publication Name	World Journal of Orthopedics
Manuscript ID	6018
Country	United States

Received	2013-09-29 18:45
Peer-Review Started	2013-09-30 15:57
To Make the First Decision	2013-11-04 14:53
Return for Revision	2013-11-11 11:03
Revised
Second Decision	2014-01-14 18:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-14 20:01
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-14 11:01
Publish the Manuscript Online	2014-05-19 12:22

ISSN	2218-5836 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Topic Highlights
Article Title	Research in spinal surgery: Evaluation and practice of evidence-based medicine
Manuscript Source	Invited Manuscript
All Author List	Mark E Oppenlander, Christopher M Maulucci, George M Ghobrial and James S Harrop
Funding Agency and Grant Number
Corresponding Author	James S Harrop, MD, Professor of Neurological Surgery, Department of Neurological Surgery, Thomas Jefferson University, 909 Walnut Street Second Floor, Philadelphia, PA 19107, United States. james.harrop@jefferson.edu
Key Words	Evidence-based medicine; Spinal surgery; Trial design; Research; Methodology
Core Tip	This paper highlights the intricacies of spinal research. The difficulties of conducting high quality research in spinal surgery are discussed, but the tools for success are outlined. Specifically, the tenets of implementing evidence-based research are provided, along with a discussion of validated outcome measures which will increase the quality of a given study design. Importantly, the randomized controlled trial should not always be considered the best study design for a given research question, and observational cohort studies may be more appropriate in certain circumstances. Ultimately, spinal surgeons are responsible for evidence-based research to justify treatment paradigms.
Publish Date	2014-05-19 12:22
Citation	Oppenlander ME, Maulucci CM, Ghobrial GM, Harrop JS. Research in spinal surgery: Evaluation and practice of evidence-based medicine. World J Orthop 2014; 5(2): 89-93
URL	http://www.wjgnet.com/2218-5836/full/v5/i2/89.htm
DOI	http://dx.doi.org/10.5312/wjo.v5.i2.89

Full Article (PDF)	WJO-5-89.pdf
Full Article (Word)	WJO-5-89.doc
Manuscript File	6018-Reviw.doc
Answering Reviewers	6018-Answering reviewers.pdf
Copyright License Agreement	6018-Copyright assignment.pdf
Peer-review Report	6018-Peer reviewer(s).pdf
Scientific Editor Work List	6018-Scientific editor work list.doc