Publication Name	World Journal of Gastroenterology
Manuscript ID	6022
Country	United States

Received	2013-09-29 19:05
Peer-Review Started	2013-09-30 15:01
First Decision by Editorial Office Director
Return for Revision	2013-11-27 18:32
Revised	2014-01-14 09:10
Publication Fee Transferred
Second Decision by Editor	2014-04-16 11:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-16 12:22
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-07 11:44
Publish the Manuscript Online	2014-05-28 11:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention
Manuscript Source	Invited Manuscript
All Author List	Faraz Bishehsari, Mahboobeh Mahdavinia, Michele Vacca, Reza Malekzadeh and Renato Mariani-Costantini
Funding Agency and Grant Number	Funding Agency Grant Number Institutional NRSA, clinical oncology research training program T32 CA079447 (Bishehsari F) Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan to Mariani-Costantini R Office for Internationalization, G. d’Annunzio University, Chieti Carichieti Foundation, Chieti Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR), Rome, Italy Fondazione Umberto Veronesi, Milan, Italy MRC (5PT57) to Vacca M
Corresponding Author	Faraz Bishehsari, MD, PhD, Division of Gastroenterology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Superior Street, Lurie 3-250, Chicago, IL 60611, United States. faraz-bishehsari@fsm.northwestern.edu
Key Words	Colorectal cancer; Developing countries; Environment; Diet; Nuclear receptors; Gut microbiota
Core Tip	This highlight addresses the rise of colorectal cancer (CRC) in the developing countries. We review the epidemiological data on the growing CRC burden in these countries, discuss the role of changing environmental risk factors, and examine preventive strategies that could contribute to control the spread of CRC. The molecular pathways of CRC and the roles of nuclear receptors and of the intestinal microbiota are discussed in the light of the current epidemiological transition.
Publish Date	2014-05-28 11:45
Citation	Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R, Mariani-Costantini R. Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol 2014; 20(20): 6055-6072
URL	http://www.wjgnet.com/1007-9327/full/v20/i20/6055.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i20.6055

Full Article (PDF)	WJG-20-6055.pdf
Full Article (Word)	WJG-20-6055.doc
Manuscript File	6022-Review.docx
Answering Reviewers	6022-Answering reviewers.pdf
Copyright License Agreement	6022-Copyright assignment.pdf
Peer-review Report	6022-Peer reviewer(s).pdf
Scientific Editor Work List	6022-Scientific editor work list.doc