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Articles Published Processes
5/26/2021 7:12:28 AM | Browse: 442 | Download: 930
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Received |
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2020-10-25 17:28 |
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Peer-Review Started |
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2020-10-25 17:29 |
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To Make the First Decision |
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Return for Revision |
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2020-12-24 18:59 |
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Revised |
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2021-01-06 19:41 |
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Second Decision |
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2021-02-20 02:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-25 19:13 |
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Articles in Press |
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2021-02-25 19:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-25 07:51 |
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Typeset the Manuscript |
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2021-05-10 08:14 |
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Publish the Manuscript Online |
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2021-05-26 07:12 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Polyglutamylase activity of tubulin tyrosine ligase like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Talita Diniz Melo-Hanchuk and Jörg Kobarg |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação de Amparo à Pesquisa do Estado São Paulo (FAPESP; São Paulo, Brazil) through Grant Temático |
2017/03489-1 |
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| Corresponding Author |
Jörg Kobarg, PhD, Full Professor, Faculty of Pharmaceutical Sciences, University of Campinas, 200 Cândido Portinari, Campinas 13083-862, Brazil. jorgkoba@unicamp.br |
| Key Words |
Kinase; Poly glutamylation; Never in mitosis gene A-related kinase 5; Tubulin tyrosine ligase like 4; Micotubles; Post translational regulation |
| Core Tip |
Tubulins are modified extensively by post-translational processes such as polyglutamylation. Considering the diversity of microtubule polyglutamylation and the existence of many non-tubulin substrates, it is important to understand how the effector enzymes, the tubulin tyrosine ligase like (TTLL) proteins, are regulated. TTLL4 interacts with never in mitosis gene A (NIMA)-related kinase 5, a member of the mitotic NIMA-related kinases. We demonstrate NIMA-related kinase 5 as a potential regulator of polyglutamylation through TTLL4’s activity control. Here we provided the first relation of regulation of TTLL4 activity through phosphorylation, besides demonstrating the potential control of polyglutamylation through Nek family members in human cells. |
| Publish Date |
2021-05-26 07:12 |
| Citation |
Melo-Hanchuk TD, Kobarg J. Polyglutamylase activity of tubulin tyrosine ligase like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5. World J Biol Chem 2021; 12(3): 38-51 |
| URL |
https://www.wjgnet.com/1949-8454/full/v12/i3/38.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v12.i3.38 |
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