Publication Name	World Journal of Gastroenterology
Manuscript ID	6034
Country	Portugal

Received	2013-09-30 08:26
Peer-Review Started	2013-10-01 20:57
To Make the First Decision	2013-10-22 16:22
Return for Revision	2013-10-23 16:19
Revised	2013-11-19 05:57
Second Decision	2013-12-05 19:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-06 12:07
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-06 09:53
Publish the Manuscript Online	2014-02-19 16:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas
Manuscript Source	Invited Manuscript
All Author List	Marta-Isabel Pereira and José Augusto Medeiros
Funding Agency and Grant Number
Corresponding Author	Marta-Isabel Pereira, MD, PhD, Institute of Physiology, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. jmedeiros@fmed.uc.pt
Key Words	Mucosa-associated lymphoid tissue lymphoma; Marginal zone lymphoma; Helicobacter pylori; Gastric lymphoma; Eradication therapy; Nuclear factor-kappa B pathway
Core Tip	Mucosa-associated lymphoid tissue (MALT) lymphomas are indolent B-cell lymphomas, originating in acquired MALT induced as a response to a chronic immunoinflammatory stimulus, notably infection by Helicobacter pylori (H. pylori). Antigenic stimulation determines lymphoid hyperplasia; additional genetic aberrations activate survival pathways, with the emergence of a malignant clone. The digestive system (predominantly the stomach) is the most frequent location, reflecting contact with foreign antigens, mucosal permeability and intrinsic lymphoid system. Early-stage gastric MALT lymphoma can regress through the eradication of H. pylori. Immortalizing genetic abnormalities, advanced disease or eradication-refractoriness require treatment alternatives, presently not consensual. Representative clinical trials are needed to optimize patient care.
Publish Date	2014-02-19 16:57
Citation	Pereira MI, Medeiros JA. Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas. World J Gastroenterol 2014; 20(3): 684-698
URL	http://www.wjgnet.com/1007-9327/full/v20/i3/684.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i3.684

Full Article (PDF)	WJG-20-684.pdf
Full Article (Word)	WJG-20-684.doc
Manuscript File	6034-Review.doc
Answering Reviewers	6034-Answering reviewers.pdf
Copyright License Agreement	6034-Copyright assignment.pdf
Peer-review Report	6034-Peer review(s).pdf
Scientific Editor Work List	6034-Scientific editor work list.doc