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Articles Published Processes
3/3/2021 10:02:01 AM | Browse: 586 | Download: 1411
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Received |
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2020-11-07 03:38 |
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Peer-Review Started |
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2020-10-30 11:58 |
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To Make the First Decision |
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Return for Revision |
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2020-12-03 06:30 |
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Revised |
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2020-12-14 08:45 |
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Second Decision |
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2021-01-30 13:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-01 21:51 |
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Articles in Press |
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2021-02-01 21:51 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-02-20 00:44 |
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Typeset the Manuscript |
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2021-03-01 01:14 |
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Publish the Manuscript Online |
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2021-03-03 10:02 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Abdominal paracentesis drainage attenuates intestinal inflammation in severe acute pancreatitis rats through inhibiting the HMGB1-mediated TLR4 signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shang-Qing Huang, Yi Wen, Hong-Yu Sun, Jie Deng, Yao-Lei Zhang, Qi-Lin Huang, Bing Wang, Zhu-Lin Luo and Li-Jun Tang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81772001 |
| National Clinical Key Subject of China |
41732113 |
| Technology Plan Program of Sichuan Province |
2019JY0277 |
| Technology Plan Program of Sichuan Province |
2020YFSY0022 |
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| Corresponding Author |
Li-Jun Tang, MD, PhD, Chief Doctor, Professor, Department of General Surgery & Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command (Chengdu Military General Hospital), No. 270 Rongdu Road, Jinniu District, Chengdu 610083, Sichuan Province, China. tanglj2016@163.com |
| Key Words |
Abdominal paracentesis drainage; Severe acute pancreatitis; High mobility group box 1; Toll-like receptor 4; Nuclear factor-κB |
| Core Tip |
We provide the first evidence that abdominal paracentesis drainage (APD) plays a protective role in intestinal inflammation and accompanying apoptosis induced by severe acute pancreatitis (SAP). Our key findings were: (1) APD decreased serum levels of indexes related to intestinal injury and improved intestinal barrier function; (2) APD alleviated intestinal inflammation and accompanying mucosal cell apoptosis; and (3) the beneficial effects of APD in ameliorating intestinal injury were due to suppressed activation of intestinal toll-like receptor 4/nuclear factor-κB signaling pathway mediated by high mobility group box protein 1. We elucidated the molecular mechanism behind APD treatment of SAP and its complications. |
| Publish Date |
2021-03-03 10:02 |
| Citation |
Huang SQ, Wen Y, Sun HY, Deng J, Zhang YL, Huang QL, Wang B, Luo ZL, Tang LJ. Abdominal paracentesis drainage attenuates intestinal inflammation in severe acute pancreatitis rats through inhibiting the HMGB1-mediated TLR4 signaling pathway. World J Gastroenterol 2021; 27(9): 815-834 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i9/815.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i9.815 |
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