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Articles Published Processes
2/20/2021 2:51:13 AM | Browse: 851 | Download: 2333
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Received |
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2020-10-26 20:17 |
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Peer-Review Started |
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2020-10-26 20:18 |
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First Decision by Editorial Office Director |
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2020-11-25 02:13 |
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Return for Revision |
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2020-11-25 02:13 |
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Revised |
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2020-11-30 09:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-01-20 13:25 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-01-21 17:46 |
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Articles in Press |
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2021-01-21 17:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-02-18 07:46 |
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Publish the Manuscript Online |
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2021-02-20 02:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mushtaq Ahmad Ansari, Mohammad Raish, Yousef A Bin Jardan, Ajaz Ahmad, Mudassar Shahid, Sheikh Fayaz Ahmad, Nazrul Haq, Mohammad Rashid Khan and Saleh A Bakheet |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research and Research Center at King Saud University |
RG-1439-083 |
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| Corresponding Author |
Mushtaq Ahmad Ansari, PhD, Associate Professor, Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, King Khalid Road, Riyadh 11451, Saudi Arabia. muansari@ksu.edu.sa |
| Key Words |
Sinapic acid; D-galactosamine/lipopolysaccharide; Oxidative stress; Fulminant hepatitis; Antioxidant; Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways |
| Core Tip |
This work demonstrated for the first time that the sinapic acid (SA) has hepatoprotective effects in the D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced rat model through its ability to suppress oxidative stress, inflammation, and apoptosis. The protective mechanism of SA depends on the downregulation of nuclear factor kappa-light-chain-enhancer of activated B cells and the restoration of antioxidant enzyme levels through the activation of the Nrf2/HO-1 pathway. Thus, SA could be applied to treat or prevent D-GalN/LPS -induced acute liver failure in the future. |
| Publish Date |
2021-02-20 02:51 |
| Citation |
Ansari MA, Raish M, Bin Jardan YA, Ahmad A, Shahid M, Ahmad SF, Haq N, Khan MR, Bakheet SA. Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways. World J Gastroenterol 2021; 27(7): 592-608 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i7/592.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i7.592 |
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