Publication Name	World Journal of Clinical Cases
Manuscript ID	60502
Country	China

Received	2021-02-25 09:45
Peer-Review Started	2021-02-25 09:45
To Make the First Decision
Return for Revision	2021-04-04 17:15
Revised	2021-04-07 13:40
Second Decision	2021-05-20 13:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-20 13:49
Articles in Press	2021-05-20 13:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-30 11:16
Typeset the Manuscript	2021-06-28 07:17
Publish the Manuscript Online	2021-07-07 08:39

ISSN	2307-8960 (online)
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Category	Respiratory System
Manuscript Type	Minireviews
Article Title	Detection of short stature homeobox 2 and RAS-associated domain family 1 subtype A DNA methylation in interventional pulmonology
Manuscript Source	Unsolicited Manuscript
All Author List	Jian Wu and Peng Li
ORCID	Author(s) ORCID Number Jian Wu http://orcid.org/0000-0002-3439-7435 Peng Li http://orcid.org/0000-0002-6060-0089
Funding Agency and Grant Number
Corresponding Author	Peng Li, MD, PhD, Attending Doctor, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. lipengcmu@163.com
Key Words	DNA methylation; interventional pulmonology; Short stature homeobox 2; RAS-associated domain family 1 subtype A; Fluid biopsy; Transbronchial needle aspiration
Core Tip	Lung cancer is the most common cancer in the world. Although the diagnosis and treatment are improved, there are still a large number of cases found with advanced stage when diagnosed. DNA methylation is the key to regulate gene expression and maintain cell characteristics. Studies showed that short stature homeobox 2 (SHOX2) promoter methylation and RAS-associated domain family 1 subtype A (RASSF1A) have been identified as biomarkers for the diagnosis of lung cancer. We review the application of SHOX2 and RASSF1A in interventional pulmonology, and introduce some of our research results in this field.
Publish Date	2021-07-07 08:39
Citation	Wu J, Li P. Detection of short stature homeobox 2 and RAS-associated domain family 1 subtype A DNA methylation in interventional pulmonology. World J Clin Cases 2021; 9(20): 5391-5397
URL	https://www.wjgnet.com/2307-8960/full/v9/i20/5391.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i20.5391

Full Article (PDF)	WJCC-9-5391.pdf
Full Article (Word)	WJCC-9-5391.docx
Manuscript File	60502_Auto_Edited-ZMG_WangTQ.docx
Answering Reviewers	60502-Answering reviewers.pdf
Audio Core Tip	60502-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	60502-Conflict-of-interest statement.pdf
Copyright License Agreement	60502-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	60502-Language certificate.pdf
Peer-review Report	60502-Peer-review(s).pdf
Scientific Misconduct Check	60502-Bing-Wang JL-1.jpg
Scientific Misconduct Check	60502-Scientific misconduct check.pdf
Scientific Editor Work List	60502-Scientific editor work list.pdf