Publication Name	World Journal of Gastroenterology
Manuscript ID	6051
Country	Singapore

Received	2013-10-01 17:22
Peer-Review Started	2013-10-01 19:03
To Make the First Decision	2013-11-13 14:56
Return for Revision	2013-11-14 11:16
Revised	2013-12-03 11:49
Second Decision	2014-01-02 11:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-02 12:13
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-12 11:35
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Prognostic biomarkers for prediction of recurrence of hepatocellular carcinoma: Current status and future prospects
Manuscript Source	Invited Manuscript
All Author List	Seow Chong Lee, Hwee Tong Tan and Maxey Ching Ming Chung
Funding Agency and Grant Number	Funding Agency Grant Number National Medical Research Council (NMRC), Singapore 1259/2010 National University of Singapore President’s Graduate Fellowship to Lee SC
Corresponding Author	Maxey Ching Ming Chung, Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore. bchcm@nus.edu.sg
Key Words	Liver cancer; Biomarker; Transcriptomics; Proteomics; Metabolomics; Recurrence
Core Tip	Hepatocellular carcinoma (HCC) patients have poor prognosis, largely due to the high incidence of recurrence. There is an urgent need for prognostic biomarkers to stratify patients with higher risk of recurrence to aid in clinical management. This review surveys the use of transcriptomics, proteomics and metabolomics in identifying prognostic biomarkers for HCC recurrence. Integration of data from various omics field allow for understanding of major pathways that were dysregulated in HCC recurrence, which could pave the way for development of personalized medicine for management of HCC recurrence.
Publish Date	2014-03-27 12:04
Citation	Lee SC, Tan HT, Chung MCM. Prognostic biomarkers for prediction of recurrence of hepatocellular carcinoma: Current status and future prospects. World J Gastroenterol 2014; 20(12): 3112-3124
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3112.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3112

Full Article (PDF)	WJG-20-3112.pdf
Full Article (Word)	WJG-20-3112.doc
Manuscript File	6051-Review.docx
Answering Reviewers	6051-Answering Reviewers.pdf
Copyright License Agreement	6051-Copyright assignment.pdf
Peer-review Report	6051-Peer review(s).pdf
Scientific Editor Work List	6051-Scientific editor work list.doc