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Articles Published Processes
9/1/2014 11:02:00 AM | Browse: 836 | Download: 720
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Received |
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2013-10-01 17:41 |
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Peer-Review Started |
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2013-10-01 19:29 |
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To Make the First Decision |
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2013-12-16 17:33 |
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Return for Revision |
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2013-12-17 19:36 |
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Revised |
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2013-12-26 04:45 |
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Second Decision |
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2014-01-20 18:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-01-20 19:24 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-03-12 20:54 |
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Publish the Manuscript Online |
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2014-03-27 12:04 |
Category |
Radiology, Nuclear Medicine & Medical Imaging |
Manuscript Type |
Topic Highlights |
Article Title |
DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker
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Manuscript Source |
Invited Manuscript |
All Author List |
Bang-Bin Chen and Tiffany Ting-Fang Shih |
Funding Agency and Grant Number |
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Corresponding Author |
Tiffany Ting-Fang Shih, MD, Department of Medical Imaging, National Taiwan University Hospital, No.7 Chung-Shan S. Rd., Taipei 100, Taiwan. ttfshih@ntu.edu.tw |
Key Words |
Dynamic contrast-enhanced magnetic resonance imaging; Perfusion magnetic resonance imaging; Hepatocellular carcinoma; Angiogenesis inhibitors; Clinical trials |
Core Tip |
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables tumor vascular physiology to be assessed. Within the tumor tissue, contrast agents extravasate from intravascular into the extravascular extracellular space, which results in a signal increase on T1-weighted MRI. These signal intensity-time curves can be deconvoluted by mathematical modeling to extract parameters that may reflect tumor angiogenesis. DCE-MRI allows us to produce highly reproducible parametric maps of quantitative parameters in hepatocellular carcinoma (HCC). In the setting of clinical trials, DCE-MRI may provide relevant clinical information of novel drugs, monitor treatment response and predict survival outcome in HCC patients. |
Publish Date |
2014-03-27 12:04 |
Citation |
Chen BB, Shih TTF. DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker. World J Gastroenterol 2014; 20(12): 3125-3134 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i12/3125.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i12.3125 |
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