Publication Name	World Journal of Gastroenterology
Manuscript ID	6056
Country	Taiwan

Received	2013-10-01 17:41
Peer-Review Started	2013-10-01 19:29
To Make the First Decision	2013-12-16 17:33
Return for Revision	2013-12-17 19:36
Revised	2013-12-26 04:45
Second Decision	2014-01-20 18:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-12 20:54
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Topic Highlights
Article Title	DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker
Manuscript Source	Invited Manuscript
All Author List	Bang-Bin Chen and Tiffany Ting-Fang Shih
Funding Agency and Grant Number
Corresponding Author	Tiffany Ting-Fang Shih, MD, Department of Medical Imaging, National Taiwan University Hospital, No.7 Chung-Shan S. Rd., Taipei 100, Taiwan. ttfshih@ntu.edu.tw
Key Words	Dynamic contrast-enhanced magnetic resonance imaging; Perfusion magnetic resonance imaging; Hepatocellular carcinoma; Angiogenesis inhibitors; Clinical trials
Core Tip	Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables tumor vascular physiology to be assessed. Within the tumor tissue, contrast agents extravasate from intravascular into the extravascular extracellular space, which results in a signal increase on T1-weighted MRI. These signal intensity-time curves can be deconvoluted by mathematical modeling to extract parameters that may reflect tumor angiogenesis. DCE-MRI allows us to produce highly reproducible parametric maps of quantitative parameters in hepatocellular carcinoma (HCC). In the setting of clinical trials, DCE-MRI may provide relevant clinical information of novel drugs, monitor treatment response and predict survival outcome in HCC patients.
Publish Date	2014-03-27 12:04
Citation	Chen BB, Shih TTF. DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker. World J Gastroenterol 2014; 20(12): 3125-3134
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3125.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3125

Full Article (PDF)	WJG-20-3125.pdf
Full Article (Word)	WJG-20-3125.doc
Manuscript File	6056-Review.docx
Answering Reviewers	6056-Answering reviews.pdf
Copyright License Agreement	6056-Copyright assignment.pdf
Peer-review Report	6056-Peer review(s).pdf
Scientific Editor Work List	6056-Scientific editor work list.doc