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9/1/2014 11:02:00 AM | Browse: 836 | Download: 720
Publication Name World Journal of Gastroenterology
Manuscript ID 6056
Country/Territory Taiwan
Received
2013-10-01 17:41
Peer-Review Started
2013-10-01 19:29
To Make the First Decision
2013-12-16 17:33
Return for Revision
2013-12-17 19:36
Revised
2013-12-26 04:45
Second Decision
2014-01-20 18:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 19:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-12 20:54
Publish the Manuscript Online
2014-03-27 12:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type Topic Highlights
Article Title DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker
Manuscript Source Invited Manuscript
All Author List Bang-Bin Chen and Tiffany Ting-Fang Shih
Funding Agency and Grant Number
Corresponding Author Tiffany Ting-Fang Shih, MD, Department of Medical Imaging, National Taiwan University Hospital, No.7 Chung-Shan S. Rd., Taipei 100, Taiwan. ttfshih@ntu.edu.tw
Key Words Dynamic contrast-enhanced magnetic resonance imaging; Perfusion magnetic resonance imaging; Hepatocellular carcinoma; Angiogenesis inhibitors; Clinical trials
Core Tip Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables tumor vascular physiology to be assessed. Within the tumor tissue, contrast agents extravasate from intravascular into the extravascular extracellular space, which results in a signal increase on T1-weighted MRI. These signal intensity-time curves can be deconvoluted by mathematical modeling to extract parameters that may reflect tumor angiogenesis. DCE-MRI allows us to produce highly reproducible parametric maps of quantitative parameters in hepatocellular carcinoma (HCC). In the setting of clinical trials, DCE-MRI may provide relevant clinical information of novel drugs, monitor treatment response and predict survival outcome in HCC patients.
Publish Date 2014-03-27 12:04
Citation Chen BB, Shih TTF. DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker. World J Gastroenterol 2014; 20(12): 3125-3134
URL http://www.wjgnet.com/1007-9327/full/v20/i12/3125.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i12.3125
Full Article (PDF) WJG-20-3125.pdf
Full Article (Word) WJG-20-3125.doc
Manuscript File 6056-Review.docx
Answering Reviewers 6056-Answering reviews.pdf
Copyright License Agreement 6056-Copyright assignment.pdf
Peer-review Report 6056-Peer review(s).pdf
Scientific Editor Work List 6056-Scientific editor work list.doc