Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	6067
Country	Iran

Received	2013-10-01 18:22
Peer-Review Started	2013-10-01 20:15
First Decision by Editorial Office Director
Return for Revision	2013-11-12 19:14
Revised
Publication Fee Transferred
Second Decision by Editor	2014-04-17 14:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-17 15:05
Articles in Press
Edit the Manuscript by Language Editor	2014-04-27 11:20
Typeset the Manuscript	2014-05-19 07:55
Publish the Manuscript Online	2014-05-20 17:09

ISSN	2150-5330 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Letter to the Editor
Article Title	Controversial issues regarding the roles of IL-10 and IFN-γ in active/inactive chronic hepatitis B
Manuscript Source	Invited Manuscript
All Author List	Hossein Khorramdelazad, Gholamhossein Hassanshahi and Mohammad Kazemi Arababadi
Funding Agency and Grant Number
Corresponding Author	Dr. Mohammad Kazemi Arababadi, Immunology of Infectious Disease Research Center, Rafsanjan University of Medical Sciences, Enghelab Square, Takhti Avenue, 7719617996 Rafsanjan, Iran. dr.kazemi@rums.ac.ir
Key Words	Hepatitis B virus; Interferon-γ; Interleukin-10
Core Tip	Cytokines play a central role in the induction of appropriate immune responses against hepatitis B, as well as the clinical manifestations of the disease. Dimitropoulou et al showed that serum levels of interleukin 10 and interferon-γ decreased in patients with HBeAg-negative chronic active hepatitis B compared with inactive hepatitis B virus (HBV) carriers (Dimitropoulou et al, 2013) and concluded that this can lead to liver disease. However, we challenge their conclusion because we believe that inappropriate host immune responses are the main causes responsible for the clinical manifestations of the disease, but not the actual replication of the HBV particles.
Publish Date	2014-05-20 17:09
Citation	Khorramdelazad H, Hassanshahi G, Arababadi MK. Controversial issues regarding the roles of IL-10 and IFN-γ in active/inactive chronic hepatitis B. World J Gastrointest Pathophysiol 2014; 5(2): 120-121
URL	http://www.wjgnet.com/2150-5330/full/v5/i2/120.htm
DOI	http://dx.doi.org/10.4291/wjgp.v5.i2.120

Full Article (PDF)	WJGP-5-120.pdf
Full Article (Word)	WJGP-5-120.doc
Manuscript File	6067-Review.docx
Answering Reviewers	6067-Answering reviewers.pdf
Copyright License Agreement	6067-Copyright assignment.pdf
Peer-review Report	6067-Peer review(s).pdf
Scientific Editor Work List	6067-Scientific editor work list.doc