| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ru Zhan, Xiu-Zhu Gao, Chang Wang, Fei Peng, Xiao-Mei Wang, Hong-Qin Xu and Jun-Qi Niu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chinese Foundation for Hepatitis Prevention and Control—Tian-Qing Liver Disease Research Fund Subject |
TQGB20200118 |
|
| Corresponding Author |
Jun-Qi Niu, MD, PhD, Academic Research, Dean, Director, Director, Doctor, Doctor, Professor, Research Scientist, Department of Hepatology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. junqiniu@jlu.edu.cn |
| Key Words |
Hepatitis B virus; Hepatitis B; Chronic; 4-1BB; Soluble 4-1BB; Hepatitis B virus serum marker |
| Core Tip |
Over 240 million people all round the world are chronically infected with hepatitis B virus, resulting in > 1 million deaths per year. Previous studies have suggested that the costimulatory molecule 4-1BB, plays pivotal roles in regulating immunity during chronic viral infection. However, up to now, there is no study about 4-1BB expression in chronic hepatitis B to clarify the role of 4-1BB in the process of chronic hepatitis B clearly. Here, we report our comprehensive study on the expression levels of soluble 4-1BB in plasma and 4-1BB mRNA in peripheral blood mononuclear cells to further explain it. |
| Publish Date |
2021-03-01 03:51 |
| Citation |
Zhan MR, Gao XZ, Wang C, Peng F, Wang XM, Xu HQ, Niu JQ. Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B. World J Clin Cases 2021; 9(7): 1619-1630 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i7/1619.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i7.1619 |
