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Articles Published Processes
2/26/2021 5:58:37 AM | Browse: 794 | Download: 1147
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Received |
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2020-11-11 21:57 |
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Peer-Review Started |
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2020-11-11 21:57 |
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To Make the First Decision |
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Return for Revision |
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2020-12-17 23:05 |
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Revised |
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2020-12-24 04:15 |
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Second Decision |
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2021-01-21 13:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-01-21 18:32 |
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Articles in Press |
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2021-01-21 18:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-01-25 19:23 |
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Typeset the Manuscript |
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2021-02-08 03:15 |
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Publish the Manuscript Online |
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2021-02-26 05:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming Yang and Chun-Ye Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, One hospital Dr. Medical Science Building, Columbia, MO 65212, United States. yangmin@health.missouri.edu |
| Key Words |
Nonalcoholic fatty liver disease; G protein-coupled receptors; Metabolism; Bile acids; Short-chain fatty acids; Gut microbiota |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Without effective treatment, NAFLD can progress to fibrosis, cirrhosis, and final liver cancer. Currently, there is no efficacy treatment option, except the preventative strategies such as diet selection and excises. G protein-coupled receptors (GPCRs) have been shown to play essential roles in metabolic disorders, such as NAFLD and obesity, through their function as receptors for bile acids and free fatty acids. Therapies such as probiotics and GPCR agonists could be applied to modulate GPCR function to ameliorate liver metabolism syndrome. Herein, this review summarizes the current findings regarding the role of GPCRs in the development and progression of NAFLD and describes some preclinical and clinical studies of GPCR-mediated treatment. |
| Publish Date |
2021-02-26 05:58 |
| Citation |
Yang M, Zhang CY. G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. World J Gastroenterol 2021; 27(8): 677-691 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i8/677.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i8.677 |
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