Publication Name	World Journal of Gastroenterology
Manuscript ID	6085
Country	Singapore

Received	2013-10-01 20:35
Peer-Review Started	2013-10-01 21:47
To Make the First Decision	2013-10-29 12:37
Return for Revision	2013-10-29 18:58
Revised	2013-11-07 11:22
Second Decision	2013-11-18 20:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-19 12:08
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-26 17:32
Publish the Manuscript Online	2013-12-18 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Helicobacter pylori γ-glutamyl transpeptidase: A formidable virulence factor
Manuscript Source	Invited Manuscript
All Author List	Samantha Shi Min Ling, Khay Guan Yeoh and Bow Ho
Funding Agency and Grant Number	Funding Agency Grant Number Singapore National Medical Research Council R182000180213
Corresponding Author	Bow Ho, Professor, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore. bow_ho@nuhs.edu.sg
Key Words	Helicobacter pylori; Gamma-glutamyl transpeptidase; Pathogenesis; Immunomodulation; Carcinogenesis
Core Tip	Helicobacter pylori produce γ-glutamyl transpeptidase (HpGGT), an important virulence factor associated with the development of peptic ulcer disease. HpGGT acts through several pathways to damage gastric epithelial cells including induction of apoptosis and cell cycle arrest, production of reactive oxygen species, promotion of inflammation and upregulation of heparin-binding epidermal growth factor-like growth factor which may then lead to carcinogenesis. HpGGT also has immunomodulatory actions on immune cells where it displays an antiproliferative effect on T cells and skews dendritic cells towards a tolerogenic phenotype, possibly contributing to the persistence of the pathogen in the gastric mucosa.
Publish Date	2013-12-18 10:39
Citation	Ling SSM, Yeoh KG, Ho B. Helicobacter pylori ?-glutamyl transpeptidase: A formidable virulence factor. World J Gastroenterol 2013; 19(45): 8203-8210
URL	http://www.wjgnet.com/1007-9327/full/v19/i45/8203.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i45.8203

Full Article (PDF)	WJG-19-8203.pdf
Manuscript File	6085-Review.doc
Answering Reviewers	6085-Answering reviewers.pdf
Copyright License Agreement	6085-Copyright assignment.pdf
Peer-review Report	6085-Peer review(s).pdf
Scientific Editor Work List	6085-Scientific editor work list.doc