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8/27/2014 4:30:00 PM | Browse: 496 | Download: 216
Publication Name World Journal of Biological Chemistry
Manuscript ID 6093
Country/Territory Canada
2013-10-02 10:11
Peer-Review Started
2013-10-02 14:55
To Make the First Decision
2013-11-12 14:33
Return for Revision
2013-11-12 19:15
2013-11-15 01:55
Second Decision
2013-12-10 16:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-12-11 10:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-26 11:19
Publish the Manuscript Online
2014-03-19 21:35
ISSN 1949-8454 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Review
Article Title Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance
Manuscript Source Invited Manuscript
All Author List Paul Linsdell
Funding Agency and Grant Number
Corresponding author Paul Linsdell, PhD, Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. paul.linsdell@dal.ca
Keywords Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Chloride channel; Open channel block; Channel pore; Permeation; Anion secretion; Potentiators
Core Tip This review summarizes our understanding of small molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) by blocking the channel pore. It describes how such inhibitors could be used in the treatment of diarrhea and hereditary kidney disease; how studying these inhibitors’ mechanisms of action has led to advances in our understanding of CFTR channel structure and function; and how substances acting via this mechanism could contribute to the physiological control of CFTR function in epithelial cells. Ironically, studying channel inhibitors has recently led to the discovery of a new class of CFTR potentiators that could be used to treat cystic fibrosis.
Publish Date 2014-03-19 21:35
Citation Linsdell P. Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance. World J Biol Chem 2014; 5(1): 26-39 Available from: URL: http://www.wjgnet.com/1949-8454/full/v5/i1/26.htm DOI: http://dx.doi.org/10.4331/wjbc.v5.i1.26
Url http://www.wjgnet.com/1949-8454/full/v5/i1/26.htm
DOI http://dx.doi.org/10.4331/wjbc.v5.i1.26
Full Article (PDF) wjbc-5-26.pdf
Full Article (Word) wjbc-5-26.doc
Manuscript File 6093-Review.docx
Answering Reviewers 6093-Answering reviews.pdf
Copyright License Agreement 6093-Copyright Assignment.pdf
Peer-review Report 6093-Peer review(s).pdf
Scientific Editor Work List 6093-Scientific editor work list.doc