Publication Name	World Journal of Biological Chemistry
Manuscript ID	6093
Country	Canada

Received	2013-10-02 10:11
Peer-Review Started	2013-10-02 14:55
To Make the First Decision	2013-11-12 14:33
Return for Revision	2013-11-12 19:15
Revised	2013-11-15 01:55
Second Decision	2013-12-10 16:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-11 10:00
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-26 11:19
Publish the Manuscript Online	2014-03-19 21:35

ISSN	1949-8454 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance
Manuscript Source	Invited Manuscript
All Author List	Paul Linsdell
Funding Agency and Grant Number
Corresponding Author	Paul Linsdell, PhD, Department of Physiology and Biophysics, Dalhousie University, PO Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. paul.linsdell@dal.ca
Key Words	Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Chloride channel; Open channel block; Channel pore; Permeation; Anion secretion; Potentiators
Core Tip	This review summarizes our understanding of small molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) by blocking the channel pore. It describes how such inhibitors could be used in the treatment of diarrhea and hereditary kidney disease; how studying these inhibitors’ mechanisms of action has led to advances in our understanding of CFTR channel structure and function; and how substances acting via this mechanism could contribute to the physiological control of CFTR function in epithelial cells. Ironically, studying channel inhibitors has recently led to the discovery of a new class of CFTR potentiators that could be used to treat cystic fibrosis.
Publish Date	2014-03-19 21:35
Citation	Linsdell P. Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance. World J Biol Chem 2014; 5(1): 26-39 Available from: URL: http://www.wjgnet.com/1949-8454/full/v5/i1/26.htm DOI: http://dx.doi.org/10.4331/wjbc.v5.i1.26
URL	http://www.wjgnet.com/1949-8454/full/v5/i1/26.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i1.26

Full Article (PDF)	wjbc-5-26.pdf
Full Article (Word)	wjbc-5-26.doc
Manuscript File	6093-Review.docx
Answering Reviewers	6093-Answering reviews.pdf
Copyright License Agreement	6093-Copyright Assignment.pdf
Peer-review Report	6093-Peer review(s).pdf
Scientific Editor Work List	6093-Scientific editor work list.doc