BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/29/2014 2:41:00 PM | Browse: 1569 | Download: 1678
 |
Received |
|
2013-10-02 10:36 |
|
Peer-Review Started |
|
2013-10-02 20:31 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2013-11-05 19:01 |
|
Revised |
|
2013-11-27 01:25 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2014-01-05 15:04 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2014-01-05 15:14 |
|
Articles in Press |
|
|
|
Edit the Manuscript by Language Editor |
|
2014-03-03 17:28 |
|
Typeset the Manuscript |
|
2014-03-25 20:40 |
|
Publish the Manuscript Online |
|
2014-04-14 10:49 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Chemopreventive drugs: Mechanisms via inhibition of cancer stem cells in colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tae Il Kim |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Tae Il Kim, MD, PhD, Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun-gu, Seoul 120-752, South Korea. taeilkim@yuhs.ac |
| Key Words |
Colorectal cancer; Chemoprevention; Cancer stem cell; Carcinogenesis; Microenvironment |
| Core Tip |
To develop optimal chemopreventive agents, we need to target cells and pathways that are essential and critical to carcinogenesis: early tumorigenic changes of stem cells and signals for dedifferentiation may be good targets for chemoprevention. Major chemopreventive drugs, such as non-steroidal anti-inflammatory drugs, statins, proliferator-activated receptor γ agonists and metformin, have cancer stem cell (CSC)-suppressing effects via regulation of stem cell-regulating pathways, stem cell niche in the tumor microenvironment, and altered tumor metabolism. These stem cell-related steps in tumorigenesis could be critical targets for chemoprevention and CSC-targeted adjunctive treatment of colorectal cancer. |
| Publish Date |
2014-04-14 10:49 |
| Citation |
Kim TI. Chemopreventive drugs: Mechanisms via inhibition of cancer stem cells in colorectal cancer. World J Gastroenterol 2014; 20(14): 3835-3846
|
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i14/3835.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i14.3835 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
