Publication Name	World Journal of Gastroenterology
Manuscript ID	6106
Country	China

Received	2013-10-03 17:34
Peer-Review Started	2013-10-03 18:53
First Decision by Editorial Office Director
Return for Revision	2013-10-23 19:39
Revised	2013-11-02 01:26
Publication Fee Transferred
Second Decision by Editor	2013-11-18 20:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-11-19 12:10
Articles in Press
Edit the Manuscript by Language Editor	2013-12-12 10:30
Typeset the Manuscript	2013-12-29 19:43
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Ming-Ming He, Dong-Sheng Zhang, Feng Wang, Zhi-Qiang Wang, Hui-Yan Luo, Chao Ren, Ying Jin, Dong-Liang Chen and Rui-Hua Xu
Funding Agency and Grant Number	Funding Agency Grant Number National High-tech R&D Program of China (863 Program) 2012AA02A506 Science and Technology Department of Guangdong Province, China 2012B031800088 Medical Scientific Research Foundation of Guangdong Province, China C2011019
Corresponding Author	Rui-Hua Xu, MD, PhD, Professor, Vice-President, State Key Laboratory of Oncology in South China, Department of Medical Oncology, Sun Yat-sen University Cancer Center, No. 651, Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. xurh@sysucc.org.cn
Key Words	Gastric adenocarcinoma; Adjuvant chemotherapy; p53; Carcinoembryonic antigen; Immunohistochemistry
Core Tip	Patients after D2 gastrectomy for stage Ⅱ/Ⅲ gastric adenocarcinoma had a significant survival benefit after adjuvant chemotherapy compared with surgery alone, which was maintained when restricted to stage Ⅱ, Ⅲ or ⅢB/ⅢC patients. The survival did not differ significantly between the patients with p53(+) and p53(-) tumors, or between patients with carcinoembryonic antigen (CEA)(+) and CEA(-) tumors, which were maintained when the analyses were restricted to surgery alone, adjuvant chemotherapy and even different chemotherapy regimens. p53 and CEA immunohistochemical expression is not prognostic for survival after D2 gastrectomy.
Publish Date	2014-01-20 17:10
Citation	He MM, Zhang DS, Wang F, Wang ZQ, Luo HY, Ren C, Jin Y, Chen DL, Xu RH. Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma. World J Gastroenterol 2014; 20(1): 264-273
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/264.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.264

Full Article (PDF)	WJG-20-264.pdf
Full Article (Word)	WJG-20-264.doc
Manuscript File	6106-Review.doc
Answering Reviewers	6106-Answering Reviewers.pdf
Copyright License Agreement	6106-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	6106-Language certificate.PDF
Peer-review Report	6106-Peer review(s).pdf