| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ming-Ming He, Dong-Sheng Zhang, Feng Wang, Zhi-Qiang Wang, Hui-Yan Luo, Chao Ren, Ying Jin, Dong-Liang Chen and Rui-Hua Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High-tech R&D Program of China (863 Program) |
2012AA02A506 |
| Science and Technology Department of Guangdong Province, China |
2012B031800088 |
| Medical Scientific Research Foundation of Guangdong Province, China |
C2011019 |
|
| Corresponding Author |
Rui-Hua Xu, MD, PhD, Professor, Vice-President, State Key Laboratory of Oncology in South China, Department of Medical Oncology, Sun Yat-sen University Cancer Center, No. 651, Dongfeng East Road, Guangzhou 510060, Guangdong Province, China. xurh@sysucc.org.cn |
| Key Words |
Gastric adenocarcinoma; Adjuvant chemotherapy; p53; Carcinoembryonic antigen; Immunohistochemistry |
| Core Tip |
Patients after D2 gastrectomy for stage Ⅱ/Ⅲ gastric adenocarcinoma had a significant survival benefit after adjuvant chemotherapy compared with surgery alone, which was maintained when restricted to stage Ⅱ, Ⅲ or ⅢB/ⅢC patients. The survival did not differ significantly between the patients with p53(+) and p53(-) tumors, or between patients with carcinoembryonic antigen (CEA)(+) and CEA(-) tumors, which were maintained when the analyses were restricted to surgery alone, adjuvant chemotherapy and even different chemotherapy regimens. p53 and CEA immunohistochemical expression is not prognostic for survival after D2 gastrectomy. |
| Publish Date |
2014-01-20 17:10 |
| Citation |
He MM, Zhang DS, Wang F, Wang ZQ, Luo HY, Ren C, Jin Y, Chen DL, Xu RH. Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma. World J Gastroenterol 2014; 20(1): 264-273 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i1/264.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i1.264 |
