| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Patients with functional bowel disorder have disaccharidase deficiency: A single-center study from Russia
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Saria Dbar, Olga Akhmadullina, Elena Sabelnikova, Nikolai Belostotskiy, Asfold Parfenov, Svetlana Bykova, Sergey Bakharev, Elena Baulo, Alexandra Babanova, Lilia Indeykina, Tatyana Kuzmina, Tatiana Kosacheva, Aleksey Spasenov and Alina Makarova |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Saria Dbar, MD, Academic Fellow, Non-inflammatory Bowel Diseases, Moscow Health Department, Moscow Clinical Scientific Center n.a. A.S. Loginov, Shosse Entuziastov 86, Build 1, Moscow 111123, Russia. saradbar@yandex.ru |
| Key Words |
Maltase deficiency; Sucrase deficiency; Lactase deficiency; Disaccharidase deficiency; Irritable bowel syndrome; Functional bowel disorder |
| Core Tip |
Our study has shown that patients with functional bowel disorders (FBDs) often had a deficiency of intestinal enzymes. We supposed that there can be a different mechanism for developing FBD: a damage of the small intestine mucous membrane may result in a decreased activity of the enzymes on the brush border of enterocytes, which leads to the disorder of carbohydrates' hydrolysis and the accumulation of osmoactive substances in the lumen of the small intestine, in its turn it causes a bacterial overgrowth in the small intestine, stool disorder, abdominal pain and bloating. The timely diagnosis of disaccharidase deficiency could lead to a better prognosis in patients with FBD. |
| Publish Date |
2021-05-26 09:58 |
| Citation |
Dbar S, Akhmadullina O, Sabelnikova E, Belostotskiy N, Parfenov A, Bykova S, Bakharev S, Baulo E, Babanova A, Indeykina L, Kuzmina T, Kosacheva T, Spasenov A, Makarova A. Patients with functional bowel disorder have disaccharidase deficiency: A single-center study from Russia. World J Clin Cases 2021; 9(17): 4178-4187 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i17/4178.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i17.4178 |
