Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	61126
Country	Switzerland

Received	2020-11-24 22:08
Peer-Review Started	2020-11-24 22:08
First Decision by Editorial Office Director	2020-12-20 03:33
Return for Revision	2020-12-20 03:33
Revised	2021-01-02 20:40
Publication Fee Transferred
Second Decision by Editor	2021-01-12 00:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2021-01-21 20:50
Articles in Press	2021-01-21 20:50
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-02-01 05:58
Publish the Manuscript Online	2021-02-04 13:19

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Matteo Mueller, Marcel André Schneider, Barla Deplazes, Daniela Cabalzar-Wondberg, Andreas Rickenbacher and Matthias Turina
ORCID	Author(s) ORCID Number Matteo Mueller http://orcid.org/0000-0002-1118-156X Marcel André Schneider http://orcid.org/0000-0002-6723-8879 Barla Deplazes http://orcid.org/0000-0002-9736-5641 Daniela Cabalzar-Wondberg http://orcid.org/0000-0002-1206-3119 Andreas Rickenbacher http://orcid.org/0000-0002-4517-208X Matthias Turina http://orcid.org/0000-0002-1040-3511
Funding Agency and Grant Number
Corresponding Author	Matthias Turina, MD, PhD, Professor, Department of Surgery and Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland. matthias.turina@usz.ch
Key Words	Young-onset colorectal cancer; Tumor biology; Colorectal surgery; Tumor aggressiveness; Colorectal cancer; Colorectal cancer screening
Core Tip	We evaluated differences in tumor biology between young-onset colorectal cancer patients (< 50 years of age) and late-onset colorectal cancer (CRC) patients (≥ 50 years of age) in a Swiss tertiary cancer center over a six-year period. Parameters of interest included clinical as well as histopathological characteristics. This study reports a surprisingly high rate of CRC of young-onset, while affected patients present more frequently with locally advanced tumors, lymphatic invasion and with more frequent lymphatic metastases. This work puts cancer incidence in relation to histopathological details, mutational status, surgical parameters and selected risk factors.
Publish Date	2021-02-04 13:19
Citation	Mueller M, Schneider MA, Deplazes B, Cabalzar-Wondberg D, Rickenbacher A, Turina M. Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study. World J Gastrointest Surg 2021; 13(2): 164-175
URL	https://www.wjgnet.com/1948-9366/full/v13/i2/164.htm
DOI	https://dx.doi.org/10.4240/wjgs.v13.i2.164

Full Article (PDF)	WJGS-13-164.pdf
Full Article (Word)	WJGS-13-164.docx