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9/1/2014 11:02:00 AM | Browse: 496 | Download: 458
Publication Name World Journal of Gastroenterology
Manuscript ID 6113
Country/Territory Finland
Received
2013-10-03 18:22
Peer-Review Started
2013-10-03 21:01
To Make the First Decision
2013-11-21 19:16
Return for Revision
2013-11-22 10:26
Revised
2013-11-27 19:16
Second Decision
2014-01-05 15:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-05 15:13
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-11 19:22
Publish the Manuscript Online
2014-03-27 12:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Autobiography
Article Title Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia
Manuscript Source Invited Manuscript
All Author List Janne S Suominen, Hanna Lampela, Päivi Heikkilä, Jouko Lohi, Hannu Jalanko and Mikko P Pakarinen
Funding Agency and Grant Number
Funding Agency Grant Number
Sigrid Juselius Foundation
Finnish Pediatric Research Foundation
Corresponding author Janne S Suominen, MD, PhD, Department of Paediatric Surgery, Pediatric Liver and Gut Research Group, Children’s Hospital, University of Helsinki, Stenbäckinkatu 11, 00290 Helsinki, Finland. janne.suominen@hus.fi
Keywords Biliary atresia; Liver fibrosis; Neovascularization; Collagen 1; α-smooth muscle actin; CD34
Core Tip The majority of biliary atresia (BA) patients require liver transplantation (LTx) due to progressive hepatic fibrosis and associated portal hypertension. We aimed to relate expression of collagen 1, α-smooth muscle actin (α-SMA) and CD34 to the most essential portoenterostomy (PE) outcomes. Collagen 1, α-SMA and CD34 were markedly overexpressed in BA patients compared with controls and centrizonal neovascularization was increased in BA. Patients who underwent LTx by age of two years had significantly higher expression of collagen 1, α-SMA and CD34 at PE compared with native liver survivors. Fibrogenesis and neovascularization are enhanced in BA, progress with increasing PE age and relate to native liver survival and development of esophageal varices.
Publish Date 2014-03-27 12:04
Citation Suominen JS, Lampela H, Heikkil? P, Lohi J, Jalanko H, Pakarinen MP. Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia. World J Gastroenterol 2014; 20(12): 3312-3319
Url http://www.wjgnet.com/1007-9327/full/v20/i12/3312.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i12.3312
Full Article (PDF) WJG-20-3312.pdf
Full Article (Word) WJG-20-3312.doc
Manuscript File 6113-Review.doc
Answering Reviewers 6113-Answering reviewer.pdf
Copyright License Agreement 6113-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6113-Language certificate.pdf
Peer-review Report 6113-Peer review(s).pdf
Scientific Editor Work List 6113-Scientific editor work list.doc