Publication Name	World Journal of Gastroenterology
Manuscript ID	6113
Country	Finland

Received	2013-10-03 18:22
Peer-Review Started	2013-10-03 21:01
To Make the First Decision	2013-11-21 19:16
Return for Revision	2013-11-22 10:26
Revised	2013-11-27 19:16
Second Decision	2014-01-05 15:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-05 15:13
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-11 19:22
Publish the Manuscript Online	2014-03-27 12:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Autobiography
Article Title	Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia
Manuscript Source	Invited Manuscript
All Author List	Janne S Suominen, Hanna Lampela, Päivi Heikkilä, Jouko Lohi, Hannu Jalanko and Mikko P Pakarinen
Funding Agency and Grant Number	Funding Agency Grant Number Sigrid Juselius Foundation Finnish Pediatric Research Foundation
Corresponding Author	Janne S Suominen, MD, PhD, Department of Paediatric Surgery, Pediatric Liver and Gut Research Group, Children’s Hospital, University of Helsinki, Stenbäckinkatu 11, 00290 Helsinki, Finland. janne.suominen@hus.fi
Key Words	Biliary atresia; Liver fibrosis; Neovascularization; Collagen 1; α-smooth muscle actin; CD34
Core Tip	The majority of biliary atresia (BA) patients require liver transplantation (LTx) due to progressive hepatic fibrosis and associated portal hypertension. We aimed to relate expression of collagen 1, α-smooth muscle actin (α-SMA) and CD34 to the most essential portoenterostomy (PE) outcomes. Collagen 1, α-SMA and CD34 were markedly overexpressed in BA patients compared with controls and centrizonal neovascularization was increased in BA. Patients who underwent LTx by age of two years had significantly higher expression of collagen 1, α-SMA and CD34 at PE compared with native liver survivors. Fibrogenesis and neovascularization are enhanced in BA, progress with increasing PE age and relate to native liver survival and development of esophageal varices.
Publish Date	2014-03-27 12:04
Citation	Suominen JS, Lampela H, Heikkil? P, Lohi J, Jalanko H, Pakarinen MP. Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia. World J Gastroenterol 2014; 20(12): 3312-3319
URL	http://www.wjgnet.com/1007-9327/full/v20/i12/3312.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i12.3312

Full Article (PDF)	WJG-20-3312.pdf
Full Article (Word)	WJG-20-3312.doc
Manuscript File	6113-Review.doc
Answering Reviewers	6113-Answering reviewer.pdf
Copyright License Agreement	6113-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6113-Language certificate.pdf
Peer-review Report	6113-Peer review(s).pdf
Scientific Editor Work List	6113-Scientific editor work list.doc