Publication Name	World Journal of Gastroenterology
Manuscript ID	6114
Country	Italy

Received	2013-10-03 18:16
Peer-Review Started	2013-10-03 19:49
First Decision by Editorial Office Director
Return for Revision	2014-01-10 09:14
Revised	2014-01-18 17:22
Publication Fee Transferred
Second Decision by Editor	2014-03-10 13:28
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-10 17:22
Articles in Press
Edit the Manuscript by Language Editor	2014-03-19 04:47
Typeset the Manuscript	2014-04-28 19:35
Publish the Manuscript Online	2014-05-18 12:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Ignazio Grattagliano, Giuseppe Calamita, Tiziana Cocco, David Q-H Wang and Piero Portincasa
Funding Agency and Grant Number
Corresponding Author	Ignazio Grattagliano, MD, Italian College of General Practitioners, Bari, Pzza G Cesare, 11, 50100 Florence, 70124 Bari, Italy. i.grattagliano@semeiotica.uniba.it
Key Words	Aquaporins; Bile salts; Chronic cholestasis; Glutathione; Mitochondria; Nitrosothiols; Nitrotyrosine; Protein sulfhydryls; Thioredoxin
Core Tip	Both oxidative and nitrosative stress are associated with ongoing manifestations of chronic cholestasis, and in particular, primary biliary cirrhosis. Abnormalities in nitric oxide metabolism and thiols oxidation already occur at early stages, thus leading to the hypothesis that these biochemical events play a pathogenic role in primary biliary cirrhosis. The association of these metabolic abnormalities with the progression of the disease may indicate some biochemical parameters as early diagnostic markers of disease evolution, and may open up the potential for pharmacological intervention to inhibit intra- and extra-cellular stress events for resuming hepatocellular functions. This article summarizes the current knowledge by outlining molecular mechanisms of the disease related to these stress events.
Publish Date	2014-05-18 12:31
Citation	Grattagliano I, Calamita G, Cocco T, Wang DQH, Portincasa P. Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis. World J Gastroenterol 2014; 20(19): 5746-5759
URL	http://www.wjgnet.com/1007-9327/full/v20/i19/5746.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i19.5746

Full Article (PDF)	WJG-20-5746.pdf
Full Article (Word)	WJG-20-5746.doc
Manuscript File	6114-Review.doc
Answering Reviewers	6114-Answering review.pdf
Copyright License Agreement	6114-Copyright assignment.pdf
Peer-review Report	6114-Peer review(s).pdf
Scientific Editor Work List	6114-Scientific editor work list.doc