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Articles Published Processes
3/11/2021 8:31:02 AM | Browse: 779 | Download: 2160
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Received |
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2020-11-26 05:22 |
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Peer-Review Started |
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2020-11-26 05:22 |
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First Decision by Editorial Office Director |
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2020-12-21 05:59 |
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Return for Revision |
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2020-12-21 05:59 |
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Revised |
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2021-01-03 08:53 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-01-30 14:02 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-02-01 21:57 |
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Articles in Press |
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2021-02-01 21:57 |
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Edit the Manuscript by Language Editor |
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2021-02-04 12:54 |
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Typeset the Manuscript |
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2021-03-09 08:10 |
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Publish the Manuscript Online |
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2021-03-11 08:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Li, Hua Shang, Tao Wang, Shui-Qing Yang and Lei Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lei Li, PhD, Academic Research, Department of Pathology, University of Otago, 270 Great King Street
, Dunedin px806, New Zealand. wshililei@buaa.edu.cn |
| Key Words |
Huanglian decoction (Coptidis Rhizoma, Zingiberis Rhizoma, Folium Artemisiae Argyi, Mume Fructus); Hepatocellular carcinoma; The Cancer Genome Atlas; Gene Expression Omnibus; P53 pathway; Cell cycle; Apoptosis |
| Core Tip |
The purpose of this study was to investigate the role and mechanism of Huanglian decoction on Hepatocellular carcinoma (HCC) cells. The results showed that Huanglian decoction has a significant inhibitory effect on the growth of HCC cells. Huanglian decoction can inhibit HCC cell growth by downregulating the expression of CCNB1 to activate the p53 signaling pathway. CCNB1 is a potential therapeutic target for liver cancer. |
| Publish Date |
2021-03-11 08:31 |
| Citation |
Li M, Shang H, Wang T, Yang SQ, Li L. Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression. World J Gastroenterol 2021; 27(10): 939-958 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i10/939.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i10.939 |
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