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Articles Published Processes
4/9/2021 5:27:04 AM | Browse: 620 | Download: 1578
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Received |
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2020-12-08 11:19 |
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Peer-Review Started |
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2020-12-08 11:20 |
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To Make the First Decision |
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Return for Revision |
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2021-01-11 02:04 |
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Revised |
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2021-01-25 18:51 |
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Second Decision |
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2021-02-26 13:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-08 18:37 |
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Articles in Press |
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2021-03-08 18:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-18 09:06 |
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Typeset the Manuscript |
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2021-04-08 01:32 |
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Publish the Manuscript Online |
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2021-04-09 05:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Vascular endothelial growth factor B inhibits insulin secretion in MIN6 cells and reduces Ca2+ and cyclic adenosine monophosphate levels through PI3K/AKT pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Dan Jia, Wen-Guo Jiang, Xu Luo, Rong-Rong Li, Yu-Chi Zhao, Geng Tian and Ya-Na Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31771284 |
| National Natural Science Foundation of China Youth Project |
31702024 |
| Major Basic Research Project of Shandong Provincial Natural Science Foundation |
ZR2019ZD27 |
| Shandong Province Higher Educational Science and Technology Plan Project |
J17KA258 |
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| Corresponding Author |
Ya-Na Li, PhD, Associate Professor, Department of Pathophysiology, School of Basic Medicine, Binzhou Medical University, No. 346 Guanhai Road, Laishan District, Yantai 264003, Shandong Province, China. yaya-698@163.com |
| Key Words |
Type 2 diabetes; Insulin secretion; MIN6 cells; Vascular endothelial growth factor B; Blood glucose regulation |
| Core Tip |
Type 2 diabetes has elicited worldwide public health concerns, and mechanism regulating insulin secretion is unclear. We found that vascular endothelial growth factor B (VEGF-B) prevents MIN6 cells from secreting insulin through the PI3K-AKT (phosphatidylinositol 3-kinase-serine/threonine kinase) pathway. We have provided mechanistic insights into the effect of VEGF-B on insulin secretion and suggest VEGF-B as a new target that affects the occurrence and development of type 2 diabetes. |
| Publish Date |
2021-04-09 05:27 |
| Citation |
Jia JD, Jiang WG, Luo X, Li RR, Zhao YC, Tian G, Li YN. Vascular endothelial growth factor B inhibits insulin secretion in MIN6 cells and reduces Ca2+ and cyclic adenosine monophosphate levels through PI3K/AKT pathway. World J Diabetes 2021; 12(4): 480-498 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i4/480.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i4.480 |
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