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Articles Published Processes
4/14/2021 7:32:39 AM | Browse: 573 | Download: 1271
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Received |
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2020-12-01 12:54 |
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Peer-Review Started |
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2020-12-01 12:55 |
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To Make the First Decision |
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Return for Revision |
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2020-12-21 05:42 |
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Revised |
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2021-01-22 14:17 |
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Second Decision |
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2021-02-20 14:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-25 05:37 |
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Articles in Press |
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2021-02-25 05:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-21 16:12 |
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Typeset the Manuscript |
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2021-04-12 01:09 |
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Publish the Manuscript Online |
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2021-04-14 07:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
LGR5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Samah Abdulaali Alharbi, Dmitry A Ovchinnikov and Ernst Wolvetang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Samah Abdulaali Alharbi, PhD, Assistant Professor, Senior Scientist, Physiology Department, College of Medicine, Umm Al-Qura University, Prince Sultan bin AbdulAziz road, Makkah 24231, Saudi Arabia. saaharbi@uqu.edu.sa |
| Key Words |
Colorectal cancer; Colon cancer cell lines; Intestinal stem cell; Cancer stem cell; Leucine-rich repeat-containing G protein-coupled receptor 5; Heterogenicity |
| Core Tip |
The intestinal epithelium harbors two distinct pools of putative stem cells, the LGR5+ (leucine-rich repeat-containing G protein-coupled receptor 5) stem cell population and the Bmi-1+ (B lymphoma Moloney murine leukemia virus insertion region 1 homolog) stem cell population. Colon cancer cell lines such as Caco-2 and LoVo are extensively used in colon cancer research, and express high levels of LGR5. Here, we aimed to investigate whether colon cancer cell lines contain cancer stem cells, and characterized these cells. Using an LGR5 reporter, we characterized LGR5+ cells and revealed that Caco-2 cell line contains a classical intestinal stem cell-like population (LGR5+). However, in LoVo cell lines, stem cell-like population is more akin to the Bmi+ stem cells. |
| Publish Date |
2021-04-14 07:32 |
| Citation |
Alharbi SA, Ovchinnikov DA, Wolvetang E. LGR5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines. World J Gastroenterol 2021; 27(15): 1578-1594 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i15/1578.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i15.1578 |
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