| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Non-responsive celiac disease in children on a gluten free diet
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gopal Veeraraghavan, Amelie Therrien, Maya Degroote, Allison McKeown, Paul D Mitchell, Jocelyn A Silvester, Daniel A Leffler, Alan M Leichtner, Ciaran P Kelly and Dascha C Weir |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Boston Children's Hospital and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health |
P30DK034854 |
| Boston Children's Hospital and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health |
K23DK119584 |
| Boston Children's Hospital and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health |
T32DK07760 |
| DG Kinnear Award from the Association Quebecoise des Gastroenterologues du Quebec |
|
| Phase 2 Award from the Fonds de Recherche Sante Quebec |
|
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| Corresponding Author |
Dascha C Weir, MD, N/A, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, United States. dascha.weir@childrens.harvard.edu |
| Key Words |
Celiac disease; Non-responsive celiac disease; Children; Gluten-free diet; Constipation; Abdominal pain |
| Core Tip |
This is a retrospective chart review study of children < 18 years of age diagnosed with celiac disease (CeD) by positive serology and biopsies showing Marsh III histology to characterize non-responsive CeD (NRCD). NRCD was attributed to a wide variety of diagnoses with gluten exposure (30%) and constipation (20%) being the most common causes. Most (64%) patients improved on follow-up. Our study highlights the importance of performing a diligent search for etiologies of NRCD when there are persistent symptoms despite following a gluten-free diet and reinforces the need for close follow up in the first year of the diagnosis of CeD. |
| Publish Date |
2021-03-30 07:03 |
| Citation |
Veeraraghavan G, Therrien A, Degroote M, McKeown A, Mitchell PD, Silvester JA, Leffler DA, Leichtner AM, Kelly CP, Weir DC. Non-responsive celiac disease in children on a gluten free diet. World J Gastroenterol 2021; 27(13): 1311-1320 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i13/1311.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i13.1311 |
