Publication Name	World Journal of Hepatology
Manuscript ID	6134
Country	Pakistan

Received	2013-10-04 20:53
Peer-Review Started	2013-10-05 13:14
To Make the First Decision	2013-10-21 11:06
Return for Revision	2013-10-21 17:03
Revised	2013-11-06 15:50
Second Decision	2013-11-15 19:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 01:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-24 15:07
Typeset the Manuscript	2013-12-25 08:42
Publish the Manuscript Online	2014-01-11 22:00

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Life cycle and pathogenesis of hepatitis D virus: A review
Manuscript Source	Invited Manuscript
All Author List	Zaigham Abbas and Rafia Afzal
Funding Agency and Grant Number
Corresponding Author	Dr. Zaigham Abbas, Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi 75500, Pakistan. drzabbas@gmail.com
Key Words	Hepatitis B virus; Hepatitis D virus; Hepatitis delta antigens; Virus replication; Host-pathogen interactions; Hepatitis D virus pathogenicity; Interferon-alpha; Hepatocellular carcinoma
Core Tip	A scarcity of literature about the hepatitis D virus (HDV) life cycle and pathogenesis is clearly evident. Severity of HDV associated liver disease and lack of an efficient treatment regime therefore warrant urgent research into HDV biology. Virus entry inhibitors and isoprenylation inhibitors may play a role in preventing HDV superinfection and liver cirrhosis. As inhibition of interferon-? signaling by HDV plays a pivotal role in failure to clear the virus, testing interferon-free treatment regimens should undergo clinical trials. A low degree of heterogeneity in hepatitis delta antigen encourages the development of a vaccine using its immunogenic sequences.
Publish Date	2014-01-11 22:00
Citation	Abbas Z, Afzal R. Life cycle and pathogenesis of hepatitis D virus: A review. World J Hepatol 2013; 5(12): 666-675
URL	http://www.wjgnet.com/1948-5182/full/v5/i12/666.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i12.666

Full Article (PDF)	WJH-5-666.pdf
Full Article (Word)	WJH-5-666.doc
Manuscript File	6134-Review.docx
Answering Reviewers	6134-Answering reviewers.pdf
Copyright License Agreement	6134-Copyright assignment.pdf
Peer-review Report	6134-Peer review(s).pdf
Scientific Editor Work List	6134-Scientific editor work list.doc