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6/25/2021 9:46:23 AM | Browse: 344 | Download: 764
Publication Name World Journal of Gastroenterology
Manuscript ID 61373
Country/Territory Germany
Received
2021-02-05 12:08
Peer-Review Started
2021-02-05 12:17
To Make the First Decision
Return for Revision
2021-03-06 04:41
Revised
2021-03-20 15:11
Second Decision
2021-05-18 09:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-05-18 22:44
Articles in Press
2021-05-18 22:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-06-02 03:18
Publish the Manuscript Online
2021-06-25 09:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy
Manuscript Source Unsolicited Manuscript
All Author List Ulrike Bauer, Sabine Gerum, Falk Roeder, Stefan Münch, Stephanie E Combs, Alexander B Philipp, Enrico N De Toni, Martha M Kirstein, Arndt Vogel, Carolin Mogler, Bernhard Haller, Jens Neumann, Rickmer F Braren, Marcus R Makowski, Philipp Paprottka, Markus Guba, Fabian Geisler, Roland M Schmid, Andreas Umgelter and Ursula Ehmer
ORCID
Author(s) ORCID Number
Ulrike Bauer http://orcid.org/0000-0003-2838-2840
Sabine Gerum http://orcid.org/0000-0003-3296-0404
Falk Roeder http://orcid.org/0000-0003-3787-7386
Stefan Münch http://orcid.org/0000-0002-1745-4127
Stephanie E Combs http://orcid.org/0000-0002-5233-1536
Alexander B Philipp http://orcid.org/0000-0002-0215-9977
Enrico N De Toni http://orcid.org/0000-0002-8101-8207
Martha M Kirstein http://orcid.org/0000-0001-9415-4083
Arndt Vogel http://orcid.org/0000-0003-0560-5538
Carolin Mogler http://orcid.org/0000-0003-3400-7254
Bernhard Haller http://orcid.org/0000-0002-9723-393X
Jens Neumann http://orcid.org/0000-0001-9200-441X
Rickmer F Braren http://orcid.org/0000-0001-6039-6957
Marcus R Makowski http://orcid.org/0000-0001-7719-8236
Philipp Paprottka http://orcid.org/0000-0001-5047-4659
Markus Guba http://orcid.org/0000-0002-7778-8401
Fabian Geisler http://orcid.org/0000-0003-1545-485X
Roland M Schmid http://orcid.org/0000-0002-6945-7581
Andreas Umgelter http://orcid.org/0000-0002-3623-180X
Ursula Ehmer http://orcid.org/0000-0002-0441-1953
Funding Agency and Grant Number
Corresponding Author Ursula Ehmer, MD, PhD, Doctor, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 21, Munich 81675, Germany. ursula.ehmer@tum.de
Key Words Hepatocellular carcinoma; Transarterial chemoembolization; Stereotactic body radiation therapy; Bridging therapy; Liver transplantation
Core Tip In patients with early-stage hepatocellular carcinoma (HCC) who are not eligible for resection or ablation, liver transplantation presents a curative treatment option. To halt tumor growth during waiting time, bridging therapies such as transarterial chemoembolization (TACE), ablation, and stereotactic body radiation therapy (SBRT) are used prior to liver transplantation. In a multicenter retrospective trial with 27 HCC patients who received either TACE or SBRT alone, or a combination of TACE and SBRT, explant histopathology was analyzed to assess treatment response. Strikingly, almost all patients in the combination group exhibited no residual vital tumor by histopathology, whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response.
Publish Date 2021-06-25 09:46
Citation Bauer U, Gerum S, Roeder F, Münch S, Combs SE, Philipp AB, De Toni EN, Kirstein MM, Vogel A, Mogler C, Haller B, Neumann J, Braren RF, Makowski MR, Paprottka P, Guba M, Geisler F, Schmid RM, Umgelter A, Ehmer U. High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy. World J Gastroenterol 2021; 27(24): 3630-3642
URL https://www.wjgnet.com/1007-9327/full/v27/i24/3630.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i24.3630
Full Article (PDF) WJG-27-3630.pdf
Full Article (Word) WJG-27-3630.docx
Manuscript File 61373_Auto_Edited.docx
Answering Reviewers 61373-Answering reviewers.pdf
Audio Core Tip 61373-Audio core tip.mp3
Biostatistics Review Certificate 61373-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61373-Conflict-of-interest statement.pdf
Copyright License Agreement 61373-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 61373-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 61373-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61373-Language certificate.pdf
Supplementary Material 61373-Supplementary material.pdf
Peer-review Report 61373-Peer-review(s).pdf
Scientific Misconduct Check 61373-Scientific misconduct check.pdf
Scientific Editor Work List 61373-Scientific editor work list.pdf