Publication Name	World Journal of Gastroenterology
Manuscript ID	6151
Country	South Korea

Received	2013-10-06 17:36
Peer-Review Started	2013-10-07 12:32
To Make the First Decision	2013-11-04 20:16
Return for Revision	2013-11-05 19:46
Revised	2013-11-10 21:11
Second Decision	2013-11-29 10:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-30 01:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-13 15:51
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Prospects for nucleic acid-based therapeutics against hepatitis C virus
Manuscript Source	Invited Manuscript
All Author List	Chang Ho Lee, Ji Hyun Kim and Seong-Wook Lee
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning 2012M3A9B6055200 National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning 2013R1A2A2A01004649
Corresponding Author	Seong-Wook Lee, PhD, Professor, Department of Molecular Biology, Institute of Nanosensor and Biotechnology, Dankook University, 126, Jukjeon-dong, Suji-gu, Yongin 448-701, South Korea. swl0208@dankook.ac.kr
Key Words	Hepatitis C virus; Nucleic acid-based therapeutics; Ribozyme; Aptamer; siRNA; Antisense oligonucleotide
Core Tip	Nucleic acids have emerged as new anti-hepatitis C virus (HCV) agents due to their great specificity, chemical synthesizability, pharmaceutical amenability, and broad targeting ability. Clinical applications of nucleic acids have been delayed due to their potential immunogenicity and toxicity, low efficacy, possible off-target effects, and lack of efficient delivery vehicles. However, recent advances in delivery carriers and chemical modification methods have improved the efficacy and bioavailability of nucleic acid-based agents. Hence, nucleic acids may be attractive anti-HCV options. In this report, the current status and future prospects of ribozymes, aptamers, siRNAs, and antisense oligonucleotides as anti-HCV regimens will be discussed.
Publish Date	2014-01-20 16:41
Citation	Lee CH, Kim JH, Lee SW. Prospects for nucleic acid-based therapeutics against hepatitis C virus. World J Gastroenterol 2013; 19(47): 8949-8962
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/8949.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.8949

Full Article (PDF)	WJG-19-8949.pdf
Manuscript File	6151-Review.doc
Answering Reviewers	6151-Answering reviewers.pdf
Copyright License Agreement	6151-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6151-Language certificate.pdf
Peer-review Report	6151-Peer review(s).pdf
Scientific Editor Work List	6151-Scientific editor work list.doc