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Articles Published Processes
3/20/2021 2:13:53 AM | Browse: 616 | Download: 1581
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Received |
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2020-12-12 00:57 |
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Peer-Review Started |
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2020-12-12 00:59 |
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To Make the First Decision |
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Return for Revision |
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2021-01-07 07:07 |
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Revised |
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2021-01-15 18:25 |
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Second Decision |
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2021-02-23 06:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-09 03:38 |
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Articles in Press |
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2021-03-09 03:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-03-18 02:28 |
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Publish the Manuscript Online |
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2021-03-20 02:13 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chrystelle L Vilfranc, Li-Xiao Che, Krushna C Patra, Liang Niu, Olugbenga Olowokure, Jiang Wang, Shimul A Shah and Chun-Ying Du |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH 1 (Du CY) |
R21CA241025-01 |
| NIH (Du CY) |
RO1CA158323 |
| NCI RO1 Diversity Supplement (Du CY) |
R01CA158323-05S |
| National Center for Advancing Translational Sciences of the National Institutes of Health (Du CY) |
2UL1TR001425-05A1 |
| University of Cincinnati Center for Environmental Genetics-NIH/NIEHS award (Du CY) |
P30 ES006096 |
| Pathways to Cancer Therapeutics T32 (Du CY and Vilfranc CL) |
CA117846-12 |
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| Corresponding Author |
Chun-Ying Du, PhD, Associate Professor, Department of Cancer Biology, University of Cincinnati, 3125 Eden Avenue Room # 3216, Cincinnati, OH 45267, United States. ducg@ucmail.uc.edu |
| Key Words |
Baculovirus repeat-containing ubiquitin conjugating enzyme; Diethylnitrosamine; Mouse model; Liver fibrosis; Liver cancer; Hepatocellular carcinoma |
| Core Tip |
Upon diethylnitrosamine (DEN) exposure, baculovirus repeat-containing ubiquitin conjugating enzyme (BRUCE) liver-deficiency accelerates chronic liver diseases such as fibrosis and hepatocellular carcinoma (HCC) in mice. Our previous study established the role of BRUCE in the protection of the liver against DEN-induced liver injury and subsequent disease progression. Here we report a chronic fibrosis background induced by hepatic BRUCE knockout in mice that recapitulates the fibrosis background in HCC patients. We also report a BRUCE-dependent suppression of β-catenin activity through the suppression of protein kinase A (PKA) activity. This study provides a therapeutic potential involving the inhibition of PKA and β-catenin activities in patients with liver disease that carry BRUCE inactivating mutations resulting in BRUCE-deficiency. |
| Publish Date |
2021-03-20 02:13 |
| Citation |
Vilfranc CL, Che LX, Patra KC, Niu L, Olowokure O, Wang J, Shah SA, Du CY. BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis. World J Hepatol 2021; 13(3): 343-361 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i3/343.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i3.343 |
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