Publication Name	World Journal of Gastroenterology
Manuscript ID	6157
Country	Italy

Received	2013-10-06 17:55
Peer-Review Started	2013-10-07 12:04
To Make the First Decision	2013-12-26 11:07
Return for Revision	2013-12-27 21:15
Revised
Second Decision	2014-02-17 16:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-17 17:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-26 17:26
Typeset the Manuscript	2014-03-26 17:02
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Topic Highlights
Article Title	Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Bhavna Rani, Yuan Cao, Andrea Malfettone, Ciprian Tomuleasa, Isabel Fabregat and Gianluigi Giannelli
Funding Agency and Grant Number	Funding Agency Grant Number EU-Marie Curie Initial Training Network (ITN), FP7-PEOPLE-2012-ITN 2012 316549
Corresponding Author	Gianluigi Giannelli, MD, Department of Medical Biosciences and Human Oncology, Padiglione Semeiotica Medica, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy. gianluigi.giannelli@uniba.it
Key Words	Tissue microenvironment; Hepatocellular carcinoma; Transforming growth factor-beta; Laminin-5; Cancer stem cells; Therapy; Target therapy
Core Tip	We discuss a new hypothesis for therapeutic approaches in hepatocellular carcinoma (HCC). This novel idea is to regard the entire liver as responsible for the onset, growth and progression of HCC. In this scenario, we focus on the tissue microenvironment components as an ideal target for systemic therapies, taking into account the tumor/host interactions.
Publish Date	2014-04-17 13:27
Citation	Rani B, Cao Y, Malfettone A, Tomuleasa C, Fabregat I, Giannelli G. Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma. World J Gastroenterol 2014; 20(15): 4128-4140
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4128.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4128

Full Article (PDF)	WJG-20-4128.pdf
Full Article (Word)	WJG-20-4128.doc
Manuscript File	6157-Review.doc
Answering Reviewers	6157-Answering reviewers.pdf
Copyright License Agreement	6157-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6157-Language certificate.pdf
Peer-review Report	6157-Peer review(s).pdf
Scientific Editor Work List	6157-Scientific editor work list.doc