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8/29/2014 11:31:00 AM | Browse: 823 | Download: 976
Publication Name World Journal of Gastroenterology
Manuscript ID 6157
Country/Territory Italy
Received
2013-10-06 17:55
Peer-Review Started
2013-10-07 12:04
To Make the First Decision
2013-12-26 11:07
Return for Revision
2013-12-27 21:15
Revised
Second Decision
2014-02-17 16:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-17 17:02
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-02-26 17:26
Typeset the Manuscript
2014-03-26 17:02
Publish the Manuscript Online
2014-04-17 13:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Topic Highlights
Article Title Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Bhavna Rani, Yuan Cao, Andrea Malfettone, Ciprian Tomuleasa, Isabel Fabregat and Gianluigi Giannelli
Funding Agency and Grant Number
Funding Agency Grant Number
EU-Marie Curie Initial Training Network (ITN), FP7-PEOPLE-2012-ITN 2012 316549
Corresponding Author Gianluigi Giannelli, MD, Department of Medical Biosciences and Human Oncology, Padiglione Semeiotica Medica, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy. gianluigi.giannelli@uniba.it
Key Words Tissue microenvironment; Hepatocellular carcinoma; Transforming growth factor-beta; Laminin-5; Cancer stem cells; Therapy; Target therapy
Core Tip We discuss a new hypothesis for therapeutic approaches in hepatocellular carcinoma (HCC). This novel idea is to regard the entire liver as responsible for the onset, growth and progression of HCC. In this scenario, we focus on the tissue microenvironment components as an ideal target for systemic therapies, taking into account the tumor/host interactions.
Publish Date 2014-04-17 13:27
Citation Rani B, Cao Y, Malfettone A, Tomuleasa C, Fabregat I, Giannelli G. Role of the tissue microenvironment as a therapeutic target in hepatocellular carcinoma. World J Gastroenterol 2014; 20(15): 4128-4140
URL http://www.wjgnet.com/1007-9327/full/v20/i15/4128.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i15.4128
Full Article (PDF) WJG-20-4128.pdf
Full Article (Word) WJG-20-4128.doc
Manuscript File 6157-Review.doc
Answering Reviewers 6157-Answering reviewers.pdf
Copyright License Agreement 6157-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6157-Language certificate.pdf
Peer-review Report 6157-Peer review(s).pdf
Scientific Editor Work List 6157-Scientific editor work list.doc