Publication Name	World Journal of Gastroenterology
Manuscript ID	61618
Country	China

Received	2020-12-14 07:02
Peer-Review Started	2020-12-14 07:04
To Make the First Decision
Return for Revision	2020-12-27 20:37
Revised	2021-01-06 07:09
Second Decision	2021-05-18 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-05-18 22:45
Articles in Press	2021-05-18 22:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-22 02:10
Typeset the Manuscript	2021-06-15 11:50
Publish the Manuscript Online	2021-06-18 05:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Oncogenic tuftelin 1 as a potential molecular-targeted for inhibiting hepatocellular carcinoma growth
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Na Wu, Wen-Jie Zheng, Wen-Xin Ye, Li Wang, Ying Chen, Jie Yang, Deng-Fu Yao and Min Yao
ORCID	Author(s) ORCID Number Meng-Na Wu http://orcid.org/0000-0002-3121-383X Wen-Jie Zheng http://orcid.org/0000-0002-3073-4596 Wen-Xin Ye http://orcid.org/0000-0002-2147-4892 Li Wang http://orcid.org/0000-0003-2838-9807 Ying Chen http://orcid.org/0000-0003-3585-1289 Jie Yang http://orcid.org/0000-0001-8518-4512 Deng-Fu Yao http://orcid.org/0000-0002-3448-7756 Min Yao http://orcid.org/0000-0002-5473-0186
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81673241 Projects of the Ministry of Science and Technology, National Key Research and Development Program 2018YFC0116902 National Natural Science Foundation of China 31872738 National Natural Science Foundation of China 81873915
Corresponding Author	Deng-Fu Yao, MD, PhD, Director, Full Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Key Words	Hepatocellular carcinoma; Tuftelin 1; Prognosis; Molecular-target; Growth
Core Tip	Tuftelin1 (TUFT1) has been reported that it is regulated by hypoxia and involved in the Hedgehog signaling pathway, with overexpression in hepatocellular carcinoma (HCC) tissues or cell lines. Abnormal TUFT1 Level was significantly related to tumor size, vascular invasion, positive hepatitis B e-antigen, advanced tumor-node-metastasis stage of HCC, patients with ascites and shorter overall survival and disease-free survival. Interfering TUFT1 transcription could markedly suppress the growth and metastasis of high TUFT1 MHCC-97H cell lines in vitro through accelerating apoptosis. Moreover, increasing TUFT1 expression might promote the growth and metastasis of low TUFT1 Hep3B cell lines in vitro. The data suggested that TUFT1 is involved in HCC progression via the mechanism of inhibiting apoptosis and might serve as a potential therapeutic target for inhibiting HCC growth.
Publish Date	2021-06-18 05:06
Citation	Wu MN, Zheng WJ, Ye WX, Wang L, Chen Y, Yang J, Yao DF, Yao M. Oncogenic tuftelin 1 as a potential molecular-targeted for inhibiting hepatocellular carcinoma growth. World J Gastroenterol 2021; 27(23): 3327-3341
URL	https://www.wjgnet.com/1007-9327/full/v27/i23/3327.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i23.3327

Full Article (PDF)	WJG-27-3327.pdf
Full Article (Word)	WJG-27-3327.docx
Manuscript File	61618-Review-FilipodiaCL.docx
Answering Reviewers	61618-Answering reviewers.pdf
Audio Core Tip	61618-Audio core tip.m4a
Biostatistics Review Certificate	61618-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	61618-Conflict-of-interest statement.pdf
Copyright License Agreement	61618-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	61618-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	61618-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	61618-Language certificate.pdf
Peer-review Report	61618-Peer-review(s).pdf
Scientific Misconduct Check	61618-Scientific misconduct check.pdf
Scientific Editor Work List	61618-Scientific editor work list.pdf