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Articles Published Processes
3/2/2021 6:51:47 AM | Browse: 618 | Download: 1214
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Received |
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2020-12-21 01:02 |
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Peer-Review Started |
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2020-12-21 01:04 |
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To Make the First Decision |
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Return for Revision |
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2021-01-07 07:26 |
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Revised |
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2021-01-07 15:18 |
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Second Decision |
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2021-01-15 07:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-01-22 03:40 |
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Articles in Press |
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2021-01-22 03:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-02-08 05:26 |
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Publish the Manuscript Online |
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2021-03-02 06:51 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Anti- and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chrong-Reen Wang and Hung-Wen Tsai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chrong-Reen Wang, MD, PhD, Professor, Department of Internal Medicine, National Cheng Kung University Hospital, No. 138 Sheng-Li Road, Tainan 70403, Taiwan. wangcr@mail.ncku.edu.tw |
| Key Words |
Insulin resistance; Diabetes mellitus; Tumor necrosis factor-α-targeted therapy; Non-tumor necrosis factor-α-targeted therapy; Rheumatoid arthritis; Psoriatic arthritis |
| Core Tip |
The crucial mechanism leading to development of diabetes mellitus is the resistance of target cells to insulin, i.e. insulin resistance (IR), indicating the ineffective strength of signaling transduction from the receptor, downstream to the final substrates of insulin action. Autoimmune-mediated arthritis including rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, with the involvement of proinflammatory cytokines like tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β as their central pathogenesis, has been demonstrated to be associated with IR. Anti-TNF-α therapy, IL-1 blockade, IL-6 antagonist, Janus kinase inhibitor and phosphodiesterase type 4 blocker can reduce IR and improve diabetic hyperglycemia in autoimmune-mediated arthritis. |
| Publish Date |
2021-03-02 06:51 |
| Citation |
Wang CR, Tsai HW. Anti- and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. World J Diabetes 2021; 12(3): 238-260 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i3/238.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i3.238 |
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