Publication Name	World Journal of Gastroenterology
Manuscript ID	6169
Country	Austria

Received	2013-10-07 10:34
Peer-Review Started	2013-10-08 08:41
To Make the First Decision	2014-01-09 20:17
Return for Revision	2014-01-19 20:32
Revised
Second Decision	2014-03-13 13:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-13 16:47
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-07 19:19
Publish the Manuscript Online	2014-05-28 11:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives
Manuscript Source	Invited Manuscript
All Author List	Florian Hohla, Thomas Winder, Richard Greil, Ferenc G Rick, Norman L Block and Andrew V Schally
Funding Agency and Grant Number
Corresponding Author	Florian Hohla, MD, Ⅲrd Medical Department with Hematology, Medical Oncology, Hemostasis, Rheumatology and Infectious Diseases, Oncologic Center, Center for Clinical Cancer and Immunology Trials, Laboratory of Immunological and Molecular Cancer Research, Paracelsus Medical University of Salzburg, Müllner Hauptstrasse 48, A-5020 Salzburg, Austria. f.hohla@salk.at
Key Words	Cytotoxic analogs; Luteinizing hormone-releasing hormone; Growth hormone releasing hormone; Gastrin-releasing peptide; Peptide receptors; Epidermal growth factor receptor; Vascular endothelial growth factor; Targeted treatment; Colorectal cancer
Core Tip	Our review evaluates the most recent clinical data on therapeutic reagents designed to target the vascular endothelial growth factor and epidermal growth factor receptor signaling pathways in colorectal cancer. As colorectal cancers express receptors for bombesin/gastrin-releasing peptide, growth hormone-releasing hormone, somatostatin as well as luteinizing hormone-releasing hormone, we review the implications of these pathways in the growth of colorectal cancers and summarize experimental data and clinical studies performed to date with regard to the antiproliferative action of antagonistic peptide analogs of these receptors as well as their cytotoxic analogs and their status as drug candidates for the treatment of metastatic colorectal cancer.
Publish Date	2014-05-28 11:45
Citation	Hohla F, Winder T, Greil R, Rick FG, Block NL, Schally AV. Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives. World J Gastroenterol 2014; 20(20): 6102-6112
URL	http://www.wjgnet.com/1007-9327/full/v20/i20/6102.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i20.6102

Full Article (PDF)	WJG-20-6102.pdf
Full Article (Word)	WJG-20-6102.doc
Manuscript File	6169-Review.docx
Answering Reviewers	6169-Answearing reviewers.pdf
Copyright License Agreement	6169-Copyright assignment.pdf
Peer-review Report	6169-Peer revieweer(s).pdf
Scientific Editor Work List	6169-Scientific editor work list.doc