| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer: A case report and review of literature
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Long Zhao, Quan Wang, Shi-Dong Zhao, Jing Zhou, Ke-Wei Jiang, Ying-Jiang Ye, Shan Wang and Zhan-Long Shen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81972240 |
|
| Corresponding Author |
Zhan-Long Shen, MD, PhD, Academic Fellow, Chief Doctor, Full Professor, Pediatric Gastroenterology Fellow, Surgeon, Teacher, Department of Gastroenterological Surgery, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. shenzhanlong@pkuph.edu.cn |
| Key Words |
Colorectal liver metastases; Next generation sequencing; Neoadjuvant chemotherapy; Genetic variants; Case report; Literature review |
| Core Tip |
Colorectal cancer has high incidence rate and mortality rate, liver metastases are the main cause of its death. Although chemotherapy is an effective treatment, some patients with specific gene mutations are not sensitive to chemotherapy With advancements in next generation sequencing, we detect multiple somatic mutations in one patient with colorectal cancer who is sensitive to chemotherapy. We conducted a literature review based on the genetic mutation of this patient and the results indicate that KRAS, TP53, SMAD4, and APC were identified as being associated with poor response, whereas mutations of CREBBP and POLD1 were associated with longer overall survival. |
| Publish Date |
2021-08-24 02:07 |
| Citation |
Zhao L, Wang Q, Zhao SD, Zhou J, Jiang KW, Ye YJ, Wang S, Shen ZL. Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer: A case report and review of literature. World J Clin Cases 2021; 9(24): 7099-7109 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i24/7099.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i24.7099 |
