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Articles Published Processes
10/13/2021 12:57:54 PM | Browse: 498 | Download: 821
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Received |
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2021-01-28 03:15 |
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Peer-Review Started |
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2021-01-28 03:34 |
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To Make the First Decision |
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Return for Revision |
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2021-06-04 00:42 |
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Revised |
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2021-06-16 17:12 |
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Second Decision |
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2021-07-14 03:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-14 09:24 |
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Articles in Press |
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2021-07-14 09:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-26 01:29 |
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Typeset the Manuscript |
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2021-10-09 10:46 |
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Publish the Manuscript Online |
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2021-10-13 12:57 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guo-Jun Cao, Di Wang, Zhao-Pei Zeng, Guo-Xiang Wang, Chun-Jiu Hu and Zhi-Fang Xing |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Health and Family Planning Commission |
20154Y0141 |
| Shanghai Development Program and the Project of Huashan Hospital North, Fudan University |
HSBY2019020 |
| Shanghai "Rising Stars of Medical Talent" Youth Development Program |
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| Corresponding Author |
Zhi-Fang Xing, PhD, Professor, Staff Physician, Department of Laboratory Medicine, Huashan Hospital North, Shanghai Medical College, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China. xzfisme@163.com |
| Key Words |
Rab4a; Rab5a; Epidermal growth factor; Cell proliferation; Gastric cancer; HGC-27 cell lines |
| Core Tip |
Firstly, our data proved that Rab5a can directly interact with Rab4a. Secondly, our study provided evidence that increased level of Rab5a can promote the expression of Rab4a, but increased Rab4a expression does not significantly affect Rab5a level. Lastly, our study suggests that the interaction between Rab5a and Rab4a is important for enhanced epidermal growth factor receptor expression on the cell membrane surface, which facilitates epidermal growth factor-stimulated proliferation of gastric cancer cells. |
| Publish Date |
2021-10-13 12:57 |
| Citation |
Cao GJ, Wang D, Zeng ZP, Wang GX, Hu CJ, Xing ZF. Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells. World J Gastrointest Oncol 2021; 13(10): 1492-1505 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i10/1492.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i10.1492 |
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