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Articles Published Processes
3/18/2021 8:34:30 AM | Browse: 630 | Download: 1240
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Received |
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2020-12-18 09:07 |
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Peer-Review Started |
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2020-12-18 09:08 |
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2021-01-10 18:33 |
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2021-01-10 19:52 |
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Second Decision |
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2021-03-09 08:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-10 18:50 |
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Articles in Press |
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2021-03-10 18:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-03-18 02:28 |
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Publish the Manuscript Online |
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2021-03-18 08:34 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bahri Abayli, Cansu Abaylı and Genco Gencdal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Genco Gencdal, MD, Associate Professor, Department of Gastroenterology, Hepatology and Liver Transplantation, Koc University, School of Medicine, özel GOP hastanesi endoskopi birimi gop istanbul, İstanbul 34300, Türkiye. gencogencdal@yahoo.co.uk |
| Key Words |
Hepatitis B; Tenofovir; Chronic hepatitis; Biopsy; Liver; Fibrosis |
| Core Tip |
Hepatitis B virus is a universal health problem. There are approximately 250 million people living with hepatitis B worldwide, and approximately 600000 of these people die every year due to the virus. Viral suppression with treatment can also lead to histological healing. Recent studies have found histological improvements in sexually transmitted disease patients who received antiviral therapy. In the current study, we aimed to compare the pretreatment and post-treatment histopathological results of patients with hepatitis be antigen-negative chronic hepatitis B who have been receiving tenofovir disoproxil fumarate (TDF) treatment at our clinic for at least 5 years. A total of 50 hepatitis be antigen-negative chronic hepatitis B patients were included in the study (mean age: 47.9 ± 10.4 years, men: 27.54%). Histological improvement was observed in 78% (39) of the patients after 5 years of treatment. After the 5 years of treatment, the mean Ishak score of the patients was 1.3 ± 1.3, and the mean histologic activity index score was 4.1 ± 2.8. A 1.53 point reduction in Ishak fibrosis score was detected after long-term TDF treatment. Liver biopsies after 5 years of TDF treatment revealed a significant histological response and a regression of the necroinflammatory score compared to pretreatment liver biopsies. |
| Publish Date |
2021-03-18 08:34 |
| Citation |
Abayli B, Abaylı C, Gencdal G. Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B. World J Gastrointest Pharmacol Ther 2021; 12(2): 32-39 |
| URL |
https://www.wjgnet.com/2150-5349/full/v12/i2/32.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v12.i2.32 |
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