Publication Name	World Journal of Cardiology
Manuscript ID	61884
Country	Italy

Received	2020-12-21 19:05
Peer-Review Started	2020-12-21 19:09
To Make the First Decision
Return for Revision	2020-12-27 00:03
Revised	2021-01-06 10:01
Second Decision	2021-02-25 03:53
Accepted by Journal Editor-in-Chief	2021-02-25 15:52
Accepted by Executive Editor-in-Chief	2021-03-26 16:21
Articles in Press	2021-03-26 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-02 21:56
Typeset the Manuscript	2021-04-15 09:40
Publish the Manuscript Online	2021-07-24 15:09

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Large eustachian valve fostering paradoxical thromboembolism: Passive bystander or serial partner in crime?
Manuscript Source	Unsolicited Manuscript
All Author List	Eustaquio Maria Onorato
ORCID	Author(s) ORCID Number Eustaquio Maria Onorato http://orcid.org/0000-0002-6750-5682
Funding Agency and Grant Number
Corresponding Author	Eustaquio Maria Onorato, MD, Consultant Physician-Scientist, Invasive Cardiology, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Via C. Parea, 4, Milan 20138 , Italy. eustaquio.onorato@gmail.com
Key Words	Eustachian valve; Chiari’s network; Patent foramen ovale; Right-to-left shunt; Paradoxical embolism; Echocardiography
Core Tip	Eustachian valve is usually considered to be a benign finding in the absence of associated cardiac anomalies. Moreover, eustachian valve is frequently found in adult patients with septal abnormalities mainly patent foramen ovale. It may actively facilitate the mechanism of paradoxical embolism by directing the blood from the inferior vena cava towards the interatrial septum via patent foramen ovale into the left atrium. Therefore, the presence of such anatomic variant may represent per se an increased risk factor for left circulation thromboembolism.
Publish Date	2021-07-24 15:09
Citation	Onorato EM. Large eustachian valve fostering paradoxical thromboembolism: Passive bystander or serial partner in crime? World J Cardiol 2021; 13(7): 204-210
URL	https://www.wjgnet.com/1949-8462/full/v13/i7/204.htm
DOI	https://dx.doi.org/10.4330/wjc.v13.i7.204

Full Article (PDF)	WJC-13-204.pdf
Full Article (Word)	WJC-13-204.docx
Manuscript File	61884-Review-FilipodiaCL.docx
Answering Reviewers	61884-Answering reviewers.pdf
Audio Core Tip	61884-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	61884-Conflict-of-interest statement.pdf
Copyright License Agreement	61884-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	61884-Language certificate.pdf
Peer-review Report	61884-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	61884-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	61884-Scientific misconduct check.pdf
Scientific Editor Work List	61884-Scientific editor work list.pdf
CrossCheck Report	61884-CrossCheck report.pdf