Publication Name	World Journal of Cardiology
Manuscript ID	61910
Country	Germany

Received	2020-12-24 14:01
Peer-Review Started	2020-12-25 00:23
To Make the First Decision
Return for Revision	2021-01-11 03:39
Revised	2021-01-19 19:24
Second Decision	2021-02-03 09:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-02-12 05:13
Articles in Press	2021-02-12 05:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-02-23 22:44
Typeset the Manuscript	2021-03-19 01:27
Publish the Manuscript Online	2021-03-22 08:36

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Prospective Study
Article Title	Elevated interleukin-6 levels are associated with impaired outcome in cardiac ATTR amyloidosis
Manuscript Source	Unsolicited Manuscript
All Author List	Selina J Hein, Maximilian Knoll, Fabian Aus dem Siepen, Jennifer Furkel, Stefan Schoenland, Ute Hegenbart, Hugo A Katus, Arnt V Kristen and Mathias Konstandin
ORCID	Author(s) ORCID Number Selina J Hein http://orcid.org/0000-0003-0139-4200 Maximilian Knoll http://orcid.org/0000-0002-9037-3980 Fabian Aus dem Siepen http://orcid.org/0000-0003-4264-1722 Jennifer Furkel http://orcid.org/0000-0002-1964-4098 Stefan Schoenland http://orcid.org/0000-0002-4853-5579 Ute Hegenbart http://orcid.org/0000-0003-1917-6746 Hugo A Katus http://orcid.org/0000-0002-2293-2314 Arnt V Kristen http://orcid.org/0000-0001-7657-3700 Mathias Konstandin http://orcid.org/0000-0001-9852-1039
Funding Agency and Grant Number	Funding Agency Grant Number Alnylam Pharmaceuticals® PO 4510001138 German Research Foundation and German Center for Cardiovascular Research Funding KO-3900
Corresponding Author	Selina J Hein, MD, Consultant Physician-Scientist, Postdoc, Department of Cardiology, Pneumology and Angiology, University Hospital Heidelberg, INF 410, Heidelberg 69120, BW, Germany. selina.hein@med.uni-heidelberg.de
Key Words	Transthyretin amyloidosis; Inflammation; Heart failure; Interleukin-6; Outcome; Risk stratification
Core Tip	This was a monocentric prospective trial with 106 patients suffering from transthyretin cardiomyopathy (ATTR-CM) seeking to evaluate the prognostic value of interleukin (IL)-6 in ATTR-CM. IL-6 is associated with outcome in ATTR-CM but did not further ameliorate existing risk prediction models.
Publish Date	2021-03-22 08:36
Citation	Hein SJ, Knoll M, Siepen FAD, Furkel J, Schoenland S, Hegenbart U, Katus HA, Kristen AV, Konstandin M. Elevated interleukin-6 levels are associated with impaired outcome in cardiac ATTR amyloidosis. World J Cardiol 2021; 13(3): 55-67
URL	https://www.wjgnet.com/1949-8462/full/v13/i3/55.htm
DOI	https://dx.doi.org/10.4330/wjc.v13.i3.55

Full Article (PDF)	WJC-13-55.pdf
Full Article (Word)	WJC-13-55.docx
CONSORT 2010 Statement	61910-CONSORT-2010-Statement-revision.pdf
Manuscript File	61910-Review-FilipodiaCL.docx
Answering Reviewers	61910-Answering reviewers.pdf
Audio Core Tip	61910-Audio core tip.m4a
Biostatistics Review Certificate	61910-Biostatistics statement.pdf
Clinical Trial Registration Statement	61910-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	61910-Conflict-of-interest statement.pdf
Copyright License Agreement	61910-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	61910-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	61910-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	61910-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	61910-Language certificate.pdf
Supplementary Material	61910-Supplementary materials.pdf
Peer-review Report	61910-Peer-review(s).pdf
Scientific Misconduct Check	61910-Bing-Wang JL-1.jpg
Scientific Misconduct Check	61910-Scientific misconduct check.pdf
Scientific Editor Work List	61910-Scientific editor work list.pdf
CrossCheck Report	61910-CrossCheck report.pdf