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Articles Published Processes
8/18/2014 5:14:00 PM | Browse: 1596 | Download: 1482
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Received |
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2013-10-08 11:59 |
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Peer-Review Started |
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2013-10-08 22:50 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-01-25 14:14 |
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Revised |
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2014-02-24 05:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-05-26 16:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-05-26 16:34 |
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Articles in Press |
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2014-05-26 17:41 |
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Edit the Manuscript by Language Editor |
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2014-06-29 03:42 |
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Typeset the Manuscript |
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2014-07-25 19:16 |
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Publish the Manuscript Online |
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2014-08-18 16:49 |
| Category |
Infectious Diseases |
| Manuscript Type |
Autobiography |
| Article Title |
Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kamila Wójcik, Elżbieta Jabłonowska, Aleksandra Omulecka and Anna Piekarska |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical University, Lodz, Poland |
502-03/1-117-01/502-14-061 |
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| Corresponding Author |
Kamila Wójcik, MD, PhD, Department of Infectious Diseases and Hepatology, Medical University of ?ód?, Kniaziewicza 1/5, 91-347 ?ód?, Poland. camilaw@tlen.pl |
| Key Words |
Adipokines; Steatosis; Chronic hepatitis C; Insulin resistance; SOCS-3 gene |
| Core Tip |
To investigate the direct effect of hepatitis C virus (HCV) on insulin resistance we analyzed adipokines and homeostasis model assessment for insulin resistance (HOMA-IR) in selected chronic hepatitis C patients without metabolic disorders. In this group of patients we confirmed higher HOMA-IR values compared to healthy subjects. We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself, regardless of metabolic disorders. This is the first study to determine the impact of a wide spectrum of adipokines and HOMA-IR index on histopathological changes in liver biopsy specimens and hepatic expression of suppressor of cytokine signaling 3 mRNA. |
| Publish Date |
2014-08-18 16:49 |
| Citation |
Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol 2014; 20(30): 10449-10456 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i30/10449.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i30.10449 |
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