Publication Name	World Journal of Gastroenterology
Manuscript ID	6199
Country	Poland

Received	2013-10-08 11:59
Peer-Review Started	2013-10-08 22:50
To Make the First Decision	2014-01-24 13:24
Return for Revision	2014-01-25 14:14
Revised	2014-02-24 05:21
Second Decision	2014-05-26 16:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 16:34
Articles in Press	2014-05-26 17:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-29 03:42
Typeset the Manuscript	2014-07-25 19:16
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Autobiography
Article Title	Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Kamila Wójcik, Elżbieta Jabłonowska, Aleksandra Omulecka and Anna Piekarska
Funding Agency and Grant Number	Funding Agency Grant Number Medical University, Lodz, Poland 502-03/1-117-01/502-14-061
Corresponding Author	Kamila Wójcik, MD, PhD, Department of Infectious Diseases and Hepatology, Medical University of ?ód?, Kniaziewicza 1/5, 91-347 ?ód?, Poland. camilaw@tlen.pl
Key Words	Adipokines; Steatosis; Chronic hepatitis C; Insulin resistance; SOCS-3 gene
Core Tip	To investigate the direct effect of hepatitis C virus (HCV) on insulin resistance we analyzed adipokines and homeostasis model assessment for insulin resistance (HOMA-IR) in selected chronic hepatitis C patients without metabolic disorders. In this group of patients we confirmed higher HOMA-IR values compared to healthy subjects. We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself, regardless of metabolic disorders. This is the first study to determine the impact of a wide spectrum of adipokines and HOMA-IR index on histopathological changes in liver biopsy specimens and hepatic expression of suppressor of cytokine signaling 3 mRNA.
Publish Date	2014-08-18 16:49
Citation	Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol 2014; 20(30): 10449-10456
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10449.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10449

Full Article (PDF)	WJG-20-10449.pdf
Full Article (Word)	WJG-20-10449.doc
Manuscript File	6199-Review.doc
Answering Reviewers	6199-Answering reviewers.pdf
Copyright License Agreement	6199-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6199-Language certificate.pdf
Peer-review Report	6199-Peer review(s).pdf
Scientific Misconduct Check	6199-CrossCheck.jpg
Scientific Editor Work List	6199-Scientific editor work list.pdf