Publication Name	World Journal of Gastroenterology
Manuscript ID	6210
Country	China

Received	2013-10-09 08:35
Peer-Review Started	2013-10-09 22:20
To Make the First Decision	2014-01-15 17:58
Return for Revision	2014-01-20 22:09
Revised	2014-02-14 16:09
Second Decision	2014-03-05 14:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-05 15:19
Articles in Press	2014-05-23 11:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-30 17:53
Typeset the Manuscript	2014-06-13 11:11
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Roles of Tregs in development of hepatocellular carcinoma: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Hong-Qiang Zhao, Wei-Min Li, Zhong-Qiou Lu and Yong-Ming Yao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81130035 National Natural Science Foundation of China 81372054 National Natural Science Foundation of China 81071545 National Natural Science Foundation of China 81121004 National Basic Research Program of China 2012CB518102
Corresponding Author	Yong-Ming Yao, MD, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China. c_ff@sina.com
Key Words	Hepatocellular carcinoma; Regulatory T cells; Meta-analysis; Tumor escape; Cellular immunity
Core Tip	Association of increased populations of regulatory T cells (Tregs) with impaired immune response in hepatocellular carcinoma (HCC) patients has been proposed. This study systematically quantified the strength of this association by meta-analysis. The available literature revealed that HCC patients have more Tregs in the circulation and tumor tissue. However, more well-designed clinical studies are needed to investigate further the potential role of Tregs in the pathogenesis of HCC, because subgroup analyses based on other tumors or patient characteristics did not show any positive correlation between Tregs and such pathological states.
Publish Date	2014-06-27 10:37
Citation	Zhao HQ, Li WM, Lu ZQ, Yao YM. Roles of Tregs in development of hepatocellular carcinoma: A meta-analysis. World J Gastroenterol 2014; 20(24): 7971-7978
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7971.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7971

Full Article (PDF)	WJG-20-7971.pdf
Full Article (Word)	WJG-20-7971.doc
Manuscript File	6210-Review.doc
Answering Reviewers	6210-Answering reviewers.pdf
Copyright License Agreement	6210-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6210-Language certificate.PDF
Peer-review Report	6210-Peer review(s).pdf
Scientific Editor Work List	6210-Scientific editor work list.doc