Publication Name	World Journal of Gastroenterology
Manuscript ID	6218
Country	United States

Received	2013-10-09 09:05
Peer-Review Started	2013-10-09 23:31
To Make the First Decision	2013-12-26 11:09
Return for Revision	2013-12-26 15:44
Revised	2014-01-04 22:07
Second Decision	2014-01-20 18:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-13 11:42
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Pediatric fatty liver disease: Role of ethnicity and genetics
Manuscript Source	Invited Manuscript
All Author List	Pierluigi Marzuillo, Emanuele Miraglia del Giudice and Nicola Santoro
Funding Agency and Grant Number	Funding Agency Grant Number American Heart Association 13SDG14640038 2012 Yale Center for Clinical Investigation cholar award to Santoro N CTSA from the National Center for Advancing Translational Science UL1 RR024139
Corresponding Author	Nicola Santoro, MD, PhD, Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, PO Box 208064, New Haven, CT 06520, United States. nicola.santoro@yale.edu
Key Words	Non alcoholic fatty liver disease; Ethnicity; Patatin like phospholipase containing domain 3 gene; Obesity; Insulin resistance; Glucokinase regulatory protein; Apolipoprotein C3 gene; Farnesyl-diphosphate farnesyltransferase 1
Core Tip	The prevalence of hepatic steatosis varies among different ethnic groups. Ethnicity with the greatest prevalence of non-alcoholic fatty liver disease (NAFLD) is the Hispanic one followed by Caucasian and then African-Americans. NAFLD exhibits tight links with insulin resistance and metabolic syndrome. Several gene variants have been so far identified by Genome Wide Association Studies or by a candidate gene approach as associated with fatty liver disease. The PNPLA3 rs738409 and the GCKR rs1260326 are the strongest variants associated with fatty liver in paediatrics.
Publish Date	2014-06-21 13:56
Citation	Marzuillo P, Miraglia del Giudice E, Santoro N. Pediatric fatty liver disease: Role of ethnicity and genetics. World J Gastroenterol 2014; 20(23): 7347-7355
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7347.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7347

Full Article (PDF)	WJG-20-7347.pdf
Full Article (Word)	WJG-20-7347.doc
Manuscript File	6218-Review.doc
Answering Reviewers	6218-Answering reviewers.pdf
Copyright License Agreement	6218-Copyright assignment.pdf
Peer-review Report	6218-Peer review(s).pdf
Scientific Editor Work List	6218-Scientific editor work list.doc