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Articles Published Processes
4/9/2021 9:07:56 AM | Browse: 524 | Download: 1394
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Received |
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2021-01-14 09:53 |
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Peer-Review Started |
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2021-01-14 09:54 |
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To Make the First Decision |
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Return for Revision |
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2021-02-10 00:12 |
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Revised |
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2021-02-21 12:26 |
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Second Decision |
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2021-03-17 10:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-17 14:42 |
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Articles in Press |
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2021-03-17 14:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-31 12:20 |
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Typeset the Manuscript |
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2021-04-06 00:07 |
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Publish the Manuscript Online |
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2021-04-09 09:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Exploration of nucleos(t)ide analogues cessation in chronic hepatitis B patients with hepatitis B e antigen loss
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Xue, Meng Zhang, Tao Li, Feng Liu, Li-Xin Zhang, Xiao-Ping Fan, Bao-Hua Yang and Lei Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Natural Science Foundation |
ZR2019PH052 |
| National Key Research and Development Program of China |
2017YFC0908104 |
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| Corresponding Author |
Lei Wang, MD, Professor, Department of Infectious Diseases and Hepatology, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Road, Jinan 250033, Shandong Province, China. wlsdeygbk@163.com |
| Key Words |
Chronic hepatitis B; Hepatitis B e antigen; Nucleos(t)ide analogues; Cessation |
| Core Tip |
A considerable proportion of patients fail to achieve hepatitis B e antigen (HBeAg) seroconversion after the long-term loss of HBeAg, even if hepatitis B surface antigen loss occurs. It remains unclear whether nucleos(t)ide analogs (NAs) can be discontinued in this subset of patients. The current study included patients who discontinued NAs after achieving HBeAg loss (without hepatitis B e antibody) for long periods since 2001. We concluded that these patients may be able to discontinue NAs therapy after long-term consolidation. HBsAg at cessation < 100 IU/mL predicts sustained virological response after NAs cessation. Careful monitoring, especially in the early stages after cessation, may ensure a favorable outcome. |
| Publish Date |
2021-04-09 09:07 |
| Citation |
Xue Y, Zhang M, Li T, Liu F, Zhang LX, Fan XP, Yang BH, Wang L. Exploration of nucleos(t)ide analogues cessation in chronic hepatitis B patients with hepatitis B e antigen loss. World J Gastroenterol 2021; 27(14): 1497-1506 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i14/1497.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i14.1497 |
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