Publication Name	World Journal of Gastroenterology
Manuscript ID	6238
Country	Canada

Received	2013-10-11 09:27
Peer-Review Started	2013-10-11 11:36
To Make the First Decision	2013-10-29 12:42
Return for Revision	2013-11-01 11:29
Revised
Second Decision	2013-11-13 10:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-13 14:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-25 11:15
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Natural history and long-term clinical course of Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Hugh James Freeman
Funding Agency and Grant Number
Corresponding Author	Hugh James Freeman, MD, CM, FRCPC, FACP, Professor, Department of Medicine (Gastroenterology), University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada. hugfree@shaw.ca
Key Words	Natural history; Crohn’s disease; Age-dependent phenotypes
Core Tip	Crohn’s disease remains an intriguing heterogeneous disorder characterized by a granulomatous inflammatory process. The phenotypic clinical expression of Crohn’s disease is clearly age-onset dependent as most children and adolescents suffer more severe, more extensive and more complicated disease than most adults, and the elderly. If evaluated over a long period of time, the disease appears to be progressive, but only intermittently active, with some appearing to have prolonged periods of sub-clinical disease and others expressing complex disease with stricture formation and penetrating complications, even at the time of initial clinical presentation. Although the precise cause of Crohn’s disease remains a mystery, an increasing appreciation for the long-term natural history may permit development of more effective treatment regimens. Ultimately, however, both clinical and fundamental investigative efforts should focus on discovering the cause of the disorder since this approach may offer the best opportunity for cure.
Publish Date	2014-01-20 17:10
Citation	Freeman HJ. Natural history and long-term clinical course of Crohn’s disease. World J Gastroenterol 2014; 20(1): 31-36
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/31.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.31

Manuscript File	6238-Review.doc
Answering Reviewers	6238-Answering reviewers.pdf
Copyright License Agreement	6238-Copyright assignment.pdf
Peer-review Report	6238-Peer review(s).docx
Scientific Editor Work List	6238-Scientific editor work list.doc