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Articles Published Processes
5/10/2021 7:46:10 AM | Browse: 505 | Download: 816
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Received |
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2021-01-08 17:56 |
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Peer-Review Started |
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2021-01-08 17:57 |
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To Make the First Decision |
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Return for Revision |
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2021-02-23 01:29 |
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Revised |
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2021-03-09 21:06 |
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Second Decision |
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2021-04-19 12:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-04-22 03:30 |
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Articles in Press |
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2021-04-22 03:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-04-30 06:15 |
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Publish the Manuscript Online |
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2021-05-10 07:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Stroma-targeting strategies in pancreatic cancer: Past lessons, challenges and prospects
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Faran Polani, Patrick M Grierson and Kian-Huat Lim |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health/National Cancer Institute |
5R37CA219697-01 |
| American Cancer Society |
RSG-17-203-01-TBG |
| Alvin J. Siteman Cancer Center Siteman Investment Program (from Barnard Trust and The Foundation for Barnes-Jewish Hospital) |
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| Emerson Collective Grant |
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| Corresponding Author |
Kian-Huat Lim, MD, PhD, Associate Professor, Division of Oncology, Department of Internal Medicine, Barnes-Jewish Hospital and The Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, United States. klim@dom.wustl.edu |
| Key Words |
Stroma; Pancreatic cancer; Treatment resistance; Cancer-associated fibroblasts; Clinical trials |
| Core Tip |
Stromal desmoplasia is not only a prominent histological hallmark of pancreatic cancer, but also a biological barrier to therapies. Various strategies aimed at targeting the stroma to improve therapeutic outcomes have been largely unsuccessful. Here we comprehensively reviewed the rationales and lessons learned from various stromal-targeting strategies and provide prospect on improving these approaches in future clinical trials. |
| Publish Date |
2021-05-10 07:46 |
| Citation |
Polani F, Grierson PM, Lim KH. Stroma-targeting strategies in pancreatic cancer: Past lessons, challenges and prospects. World J Gastroenterol 2021; 27(18): 2105-2121 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i18/2105.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i18.2105 |
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